CDKN2A blocking peptide product blog
Tags: CDKN2A; Blocking Peptide; CDKN2A blocking peptide; p16-INK4A (S152);
The CDKN2A cdkn2a (Catalog #MBS9230033) is a Blocking Peptide and is intended for research purposes only. The product is available for immediate purchase.The CDKN2A cdkn2a product has the following accession number(s) (GI #3041660) (NCBI Accession #P42771.2) (Uniprot Accession #P42771). Researchers may be interested in using Bioinformatics databases such as those available at The National Center for Biotechnology Information (NCBI) website for more information about accession numbers and the proteins they represent. Even researchers unfamiliar with bioinformatics databases will find the NCBI databases to be quite user friendly and useful.
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Acts as a negative regulator of the proliferation of normal cells by interacting strongly with CDK4 and CDK6. This inhibits their ability to interact with cyclins D and to phosphorylate the retinoblastoma protein.
Cellular Location: Cytoplasm. Nucleus. Tissue Location: Widely expressed but not detected in brain or skeletal muscle. Isoform 3 is pancreas-specific. Blood, Bone, Brain, Cervix, Liver, Lung, Lymph, Lymph Node, Skin, Stomach tissues are correlated with this protein. CDKN2A also interacts with the following gene(s): CCND1, CDK4, CDK6, CDKN1A, MDM2, MYC, NPM1, RB1, TP53, UBC. The following patways have been known to be associated with this gene. Adenocarcinoma, Brain Neoplasms, Breast Neoplasms, Carcinoma, Squamous Cell, Glioma, Lung Neoplasms, Lymphoma, Melanoma, Pancreatic Neoplasms, Urogenital Neoplasms are some of the diseases may be linked to p16-INK4A(S152) Blocking Peptide.