CDKN1B blocking peptide product blog
Tags: CDKN1B; Blocking Peptide; CDKN1B blocking peptide; p27Kip1 (T170);
The CDKN1B cdkn1b (Catalog #MBS9230834) is a Blocking Peptide and is intended for research purposes only. The product is available for immediate purchase.The CDKN1B cdkn1b product has the following accession number(s) (GI #4757962) (NCBI Accession #NP_004055.1) (Uniprot Accession #P46527). Researchers may be interested in using Bioinformatics databases such as those available at The National Center for Biotechnology Information (NCBI) website for more information about accession numbers and the proteins they represent. Even researchers unfamiliar with bioinformatics databases will find the NCBI databases to be quite user friendly and useful.
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Important regulator of cell cycle progression. Involved in G1 arrest. Potent inhibitor of cyclin E- and cyclin A-CDK2 complexes. Forms a complex with cyclin type D-CDK4 complexes and is involved in the assembly, stability, and modulation of CCND1- CDK4 complex activation. Acts either as an inhibitor or an activator of cyclin type D-CDK4 complexes depending on its phosphorylation state and/or stoichometry.
Cellular Location: Nucleus. Cytoplasm. Endosome. Note: Nuclear and cytoplasmic in quiescent cells. AKT- or RSK- mediated phosphorylation on Thr-198, binds 14-3-3, translocates to the cytoplasm and promotes cell cycle progression. Mitogen- activated UHMK1 phosphorylation on Ser-10 also results in translocation to the cytoplasm and cell cycle progression Phosphorylation on Ser-10 facilitates nuclear export. Translocates to the nucleus on phosphorylation of Tyr-88 and Tyr-89 Colocalizes at the endosome with SNX6; this leads to lysosomal degradation (By similarity). Tissue Location: Expressed in all tissues tested. Highest levels in skeletal muscle, lowest in liver and kidney. The following patways have been known to be associated with this gene. Blood, Bone, Brain, Kidney, Liver, Lung, Lymph Node, Muscle, Prostate, Vascular tissues are correlated with this protein. Adenocarcinoma, Breast Neoplasms, Cell Transformation, Neoplastic, Hyperplasia, Intestinal Neoplasms, Liver Neoplasms, Lung Neoplasms, Neoplasm Metastasis, Neoplasms, Experimental, Prostatic Neoplasms are some of the diseases may be linked to Phospho-p27Kip1(T170) Blocking Peptide. CDKN1B also interacts with the following gene(s): AKT1, CCNA2, CCND1, CCND3, CCNE1, CDK2, CDK4, CDK6, SKP2, UBC.