|The Cdk8 cdk8 (Catalog #MBS9229603) is a Blocking Peptide and is intended for research purposes only. The product is available for immediate purchase.
The Cdk8 cdk8 product has the following accession number(s) (GI #134035399) (NCBI Accession #Q8R3L8.3) (Uniprot Accession #Q8R3L8). Researchers may be interested in using Bioinformatics databases such as those available at The National Center for Biotechnology Information (NCBI) website for more information about accession numbers and the proteins they represent. Even researchers unfamiliar with bioinformatics databases will find the NCBI databases to be quite user friendly and useful.
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Component of the Mediator complex, a coactivator involved in regulated gene transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors. Phosphorylates the CTD (C-terminal domain) of the large subunit of RNA polymerase II (RNAp II), which may inhibit the formation of a transcription initiation complex. Phosphorylates CCNH leading to down-regulation of the TFIIH complex and transcriptional repression. Recruited through interaction with MAML1 to hyperphosphorylate the intracellular domain of NOTCH, leading to its degradation (By similarity).
Cellular Location: Nucleus. Cdk8 also interacts with the following gene(s): Ccnc, Med10, Med13, Med14, Med15, Med21, Med23, Med24, Med6. Bone Marrow, Brain, Eye, Intestine, Kidney, Lung, Lymph Node, Pancreas, Testis, Thyroid tissues are correlated with this protein. The following patways have been known to be associated with this gene. Adenocarcinoma, Breast Neoplasms, Cardiovascular Diseases, Cell Transformation, Neoplastic, Colonic Neoplasms, Disease Models, Animal, Liver Diseases, Neoplasm Metastasis, Neoplasms, Experimental, Nervous System Diseases are some of the diseases may be linked to Mouse Cdk8 Blocking Peptide (C-term).