|The CDK5R1 cdk5r1 (Catalog #MBS9227215) is a Blocking Peptide and is intended for research purposes only. The product is available for immediate purchase.
The CDK5R1 cdk5r1 product has the following accession number(s) (GI #2498217) (NCBI Accession #Q15078.1) (Uniprot Accession #Q15078). Researchers may be interested in using Bioinformatics databases such as those available at The National Center for Biotechnology Information (NCBI) website for more information about accession numbers and the proteins they represent. Even researchers unfamiliar with bioinformatics databases will find the NCBI databases to be quite user friendly and useful.
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p35 is a neuron specific activator of CDK5. The complex p35/CDK5 is required for neurite outgrowth and cortical lamination. Involved in dendritic spine morphogenesis by mediating the EFNA1-EPHA4 signaling. Activator of TPKII. The complex p35/CDK5 participates in the regulation of the circadian clock by modulating the function of CLOCK protein: phosphorylates CLOCK at \'Thr-451\' and \'Thr-461\' and regulates the transcriptional activity of the CLOCK-ARNTL/BMAL1 heterodimer in association with altered stability and subcellular distribution.
Cellular Location: Cyclin-dependent kinase 5 activator 1, p35: Cell membrane; Lipid-anchor; Cytoplasmic side. Note: In the primary cortical neurons, p35 is present in the peripheries and nerve terminals. Tissue Location: Brain and neuron specific. CDK5R1 also interacts with the following gene(s): CAPN2, CDK16, CDK5, CDK5RAP1, GSK3B, PPP1R1B. Brain Diseases, Cardiovascular Diseases, Inflammation, Kidney Diseases, Learning Disorders, Memory Disorders, Movement Disorders, Necrosis, Nerve Degeneration, Nervous System Diseases are some of the diseases may be linked to CDK5R1(p35) Antibody (C-term) Blocking Peptide. The following patways have been known to be associated with this gene. Brain, Embryonic Tissue, Eye, Kidney, Liver, Lung, Muscle, Ovary, Pancreas, Uterus tissues are correlated with this protein.