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CDH2 peptide product blog

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Posted on 2013-11-27 14:39:50 by mybiosource_staff
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Tags: Peptide; CDH2; N-Cadherin (a.a. 811-824) Peptide; CDH2 peptide;
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The CDH2 cdh2 (Catalog #MBS474012) is a Peptide and is intended for research purposes only. The product is available for immediate purchase.
ELISA: 50 ng/well
Western Blot: 1 mg/ml. Researchers should empirically determine the suitability of the CDH2 cdh2 for an application not listed in the data sheet. Researchers commonly develop new applications and it is an integral, important part of the investigative research process.

The CDH2 cdh2 product has the following accession number(s) (GI #253483) (Uniprot Accession #P19022). Researchers may be interested in using Bioinformatics databases such as those available at The National Center for Biotechnology Information (NCBI) website for more information about accession numbers and the proteins they represent. Even researchers unfamiliar with bioinformatics databases will find the NCBI databases to be quite user friendly and useful. The amino acid sequence is listed below:
Peptide Sequence: Unphosphor ylated N-cadherin (a.a. 811-824) synthetic peptide generated from human N-cadherin. This sequence is conserved in rat and mouse Ncadherin, and has three amino acid difference s from the conserved region in R-cadherin.

To buy or view more detailed product information and pricing, please click on the technical datasheet page below:


Cadherins are transmembrane glycoproteins vital in calcium-dependent cell-cell adhesion during tissue differentiation. Cadherins cluster to form foci of homophilic binding units. A key determinant to the strength of the cadherin-mediated adhesion may be by the juxtamembrane region in cadherins. This region induces clustering and also binds to the protein p120 catenin. The cytoplasmic region is highly conserved in sequence and has been shown experimentally to regulate the cell-cell binding function of the extracellular domain of E-cadherin, possibly through interaction with the cytoskeleton. Many cadherins are regulated by phosphorylation, including N-cadherin and E-cadherin. N-cadherin is phosphorylated by c-Src at Tyr-820, Tyr-853, Tyr-860, Tyr-884, and Tyr-886. Phosphorylation of Tyr-860 can disrupt cadherin binding to beta-catenin. Since many of these tyrosine sites are conserved in the cadherin family, phosphorylation of these sites may be critical for cadherin function.

CDH2 cdh2

Adenocarcinoma, Carcinoma, Cardiovascular Diseases, Endocrine Gland Neoplasms, Female Urogenital Diseases, Lung Neoplasms, Neoplasm Metastasis, Neoplasms, Neuroectodermal Tumors, Skin Diseases are some of the diseases may be linked to N-Cadherin (a.a. 811-824) Peptide. The following patways have been known to be associated with this gene. CDH2 also interacts with the following gene(s): ARVCF, CDH11, CDH4, CTNNA1, CTNNB1, JUP. Brain tissues are correlated with this protein.
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