CD79A blocking peptide product blog
Tags: Blocking Peptide; CD79a; CD79A blocking peptide;
The CD79A cd79a (Catalog #MBS9221245) is a Blocking Peptide and is intended for research purposes only. The product is available for immediate purchase.The CD79A cd79a product has the following accession number(s) (GI #547896) (NCBI Accession #P11912.2) (Uniprot Accession #P11912). Researchers may be interested in using Bioinformatics databases such as those available at The National Center for Biotechnology Information (NCBI) website for more information about accession numbers and the proteins they represent. Even researchers unfamiliar with bioinformatics databases will find the NCBI databases to be quite user friendly and useful.
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Required in cooperation with CD79B for initiation of the signal transduction cascade activated by binding of antigen to the B-cell antigen receptor complex (BCR) which leads to internalization of the complex, trafficking to late endosomes and antigen presentation. Also required for BCR surface expression and for efficient differentiation of pro- and pre-B-cells. Stimulates SYK autophosphorylation and activation. Binds to BLNK, bringing BLNK into proximity with SYK and allowing SYK to phosphorylate BLNK. Also interacts with and increases activity of some Src- family tyrosine kinases. Represses BCR signaling during development of immature B-cells.
Cellular Location: Cell membrane; Single-pass type I membrane protein. Note: Following antigen binding, the BCR has been shown to translocate from detergent-soluble regions of the cell membrane to lipid rafts although signal transduction through the complex can also occur outside lipid rafts. Tissue Location: B-cells. Hyperplasia, Inflammation, Liver Diseases, Liver Neoplasms, Lung Diseases, Lung Neoplasms, Lymphoma, Large B-Cell, Diffuse, Necrosis, Skin Neoplasms, Splenomegaly are some of the diseases may be linked to CD79A Antibody (Center) Blocking Peptide. The following patways have been known to be associated with this gene. Blood, Heart, Intestine, Liver, Lung, Lymph, Lymph Node, Mouth, Spleen, Thymus tissues are correlated with this protein. CD79A also interacts with the following gene(s): BCR, BLNK, CD19, CD22, CD79B, FYN, LYN, SYK.