|The CD33 cd33 (Catalog #MBS9219989) is a Blocking Peptide and is intended for research purposes only. The product is available for immediate purchase.
The CD33 cd33 product has the following accession number(s) (GI #116241290) (NCBI Accession #P20138.2) (Uniprot Accession #P20138). Researchers may be interested in using Bioinformatics databases such as those available at The National Center for Biotechnology Information (NCBI) website for more information about accession numbers and the proteins they represent. Even researchers unfamiliar with bioinformatics databases will find the NCBI databases to be quite user friendly and useful.
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Putative adhesion molecule of myelomonocytic-derived cells that mediates sialic-acid dependent binding to cells. Preferentially binds to alpha-2,6-linked sialic acid. The sialic acid recognition site may be masked by cis interactions with sialic acids on the same cell surface. In the immune response, may act as an inhibitory receptor upon ligand induced tyrosine phosphorylation by recruiting cytoplasmic phosphatase(s) via their SH2 domain(s) that block signal transduction through dephosphorylation of signaling molecules. Induces apoptosis in acute myeloid leukemia (in vitro).
Cellular Location: Cell membrane; Single-pass type I membrane protein. Tissue Location: Monocytic/myeloid lineage cells. Blood, Bone, Bone Marrow, Brain, Kidney, Liver, Lung, Lymph Node, Prostate, Thymus tissues are correlated with this protein. The following patways have been known to be associated with this gene. CD33 also interacts with the following gene(s): ANPEP, CD19, CD2, CD34, CD7, CEBPA, FUT4, NCAM1, PTPN11. Alzheimer Disease, Breast Neoplasms, Cardiovascular Diseases, Inflammation, Leukemia, Myeloid, Acute, Lung Diseases, Lung Neoplasms, Necrosis, Respiratory Tract Diseases, Skin Neoplasms are some of the diseases may be linked to CD33 Antibody (Center) Blocking peptide.