CCR4 blocking peptide product blog
Tags: Blocking Peptide; CCR4; CCR4 blocking peptide;
The CCR4 ccr4 (Catalog #MBS9223163) is a Blocking Peptide and is intended for research purposes only. The product is available for immediate purchase.The CCR4 ccr4 product has the following accession number(s) (GI #1705894) (NCBI Accession #P51679.1) (Uniprot Accession #P51679). Researchers may be interested in using Bioinformatics databases such as those available at The National Center for Biotechnology Information (NCBI) website for more information about accession numbers and the proteins they represent. Even researchers unfamiliar with bioinformatics databases will find the NCBI databases to be quite user friendly and useful.
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High affinity receptor for the C-C type chemokines CCL17/TARC, CCL22/MDC and CKLF isoform 1/CKLF1. The activity of this receptor is mediated by G(i) proteins which activate a phosphatidylinositol-calcium second messenger system. Can function as a chemoattractant homing receptor on circulating memory lymphocytes and as a coreceptor for some primary HIV-2 isolates. In the CNS, could mediate hippocampal-neuron survival.
Cellular Location: Cell membrane; Multi-pass membrane protein. Tissue Location: Predominantly expressed in the thymus, in peripheral blood leukocytes, including T-cells, mostly CD4+ cells, and basophils, and in platelets; at lower levels, in the spleen and in monocytes. Detected also in macrophages, IL-2-activated natural killer cells and skin-homing memory T-cells, mostly the ones expressing the cutaneous lymphocyte antigen (CLA). Expressed in brain microvascular and coronary artery endothelial cells. CCR4 also interacts with the following gene(s): CCL17, CCL22, CCL25, CCL27, CCL3, CCL4, CCL5, CXCL12, IL8. Adipose Tissue, Blood, Brain, Lung, Thymus tissues are correlated with this protein. The following patways have been known to be associated with this gene. Death, Fibrosis, Heart Diseases, Inflammation, Leukemia-Lymphoma, Adult T-Cell, Liver Diseases, Lung Diseases, Necrosis, Pulmonary Fibrosis, Sezary Syndrome are some of the diseases may be linked to CCR4 Antibody (C-term) Blocking Peptide.