|The CASP10 casp10 (Catalog #MBS9219800) is a Blocking Peptide and is intended for research purposes only. The product is available for immediate purchase.
The CASP10 casp10 product has the following accession number(s) (GI #12644463) (NCBI Accession #Q92851.3) (Uniprot Accession #Q92851). Researchers may be interested in using Bioinformatics databases such as those available at The National Center for Biotechnology Information (NCBI) website for more information about accession numbers and the proteins they represent. Even researchers unfamiliar with bioinformatics databases will find the NCBI databases to be quite user friendly and useful.
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Involved in the activation cascade of caspases responsible for apoptosis execution. Recruited to both Fas- and TNFR-1 receptors in a FADD dependent manner. May participate in the granzyme B apoptotic pathways. Cleaves and activates caspase- 3, -4, -6, -7, -8, and -9. Hydrolyzes the small- molecule substrates, Tyr-Val-Ala-Asp-|-AMC and Asp-Glu-Val-Asp-|-AMC.
Tissue Location: Detectable in most tissues. Lowest expression is seen in brain, kidney, prostate, testis and colon. Blood, Bone, Bone Marrow, Brain, Embryonic Tissue, Heart, Lung, Lymph Node, Skin, Stomach tissues are correlated with this protein. The following patways have been known to be associated with this gene. Breast Neoplasms, Colonic Neoplasms, Inflammation, Lung Diseases, Lung Neoplasms, Lymphoma, Non-Hodgkin, Melanoma, Necrosis, Ovarian Neoplasms, Stomach Neoplasms are some of the diseases may be linked to CASP10 Antibody (Center) Blocking Peptide.