|The CAMK1 camk1 (Catalog #MBS9226674) is a Blocking Peptide and is intended for research purposes only. The product is available for immediate purchase.
The CAMK1 camk1 product has the following accession number(s) (GI #3122301) (NCBI Accession #Q14012.1) (Uniprot Accession #Q14012). Researchers may be interested in using Bioinformatics databases such as those available at The National Center for Biotechnology Information (NCBI) website for more information about accession numbers and the proteins they represent. Even researchers unfamiliar with bioinformatics databases will find the NCBI databases to be quite user friendly and useful.
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Calcium/calmodulin-dependent protein kinase that operates in the calcium-triggered CaMKK-CaMK1 signaling cascade and, upon calcium influx, regulates transcription activators activity, cell cycle, hormone production, cell differentiation, actin filament organization and neurite outgrowth. Recognizes the substrate consensus sequence [MVLIF]-x-R-x(2)-[ST]-x(3)-[MVLIF]. Regulates axonal extension and growth cone motility in hippocampal and cerebellar nerve cells. Upon NMDA receptor-mediated Ca(2+) elevation, promotes dendritic growth in hippocampal neurons and is essential in synapses for full long-term potentiation (LTP) and ERK2-dependent translational activation. Downstream of NMDA receptors, promotes the formation of spines and synapses in hippocampal neurons by phosphorylating ARHGEF7/BETAPIX on \'Ser- 694\', which results in the enhancement of ARHGEF7 activity and activation of RAC1. Promotes neuronal differentiation and neurite outgrowth by activation and phosphorylation of MARK2 on \'Ser-91\', \'Ser-92\', \'Ser-93\' and \'Ser-294\'. Promotes nuclear export of HDAC5 and binding to 14-3-3 by phosphorylation of \'Ser-259\' and \'Ser- 498\' in the regulation of muscle cell differentiation. Regulates NUMB-mediated endocytosis by phosphorylation of NUMB on \'Ser-276\' and \'Ser-295\'. Involved in the regulation of basal and estrogen- stimulated migration of medulloblastoma cells through ARHGEF7/BETAPIX phosphorylation (By similarity). Is required for proper activation of cyclin-D1/CDK4 complex during G1 progression in diploid fibroblasts. Plays a role in K(+) and ANG2-mediated regulation of the aldosterone synthase (CYP11B2) to produce aldosterone in the adrenal cortex. Phosphorylates EIF4G3/eIF4GII. In vitro phosphorylates CREB1, ATF1, CFTR, MYL9 and SYN1/synapsin I.
Cellular Location: Cytoplasm. Nucleus. Note: Predominantly cytoplasmic. Tissue Location: Widely expressed. Expressed in cells of the zona glomerulosa of the adrenal cortex. Adrenal Gland, Bone, Brain, Eye, Ganglia, Heart, Kidney, Liver, Muscle, Testis tissues are correlated with this protein. The following patways have been known to be associated with this gene. Carcinoma, Hepatocellular, Disease Models, Animal, Fibrosis, Hyperplasia, Hypertension, Hypertrophy, Kidney Diseases, Liver Diseases, Liver Neoplasms, Neoplasms, Experimental are some of the diseases may be linked to CAMK1 Antibody (C-term) Blocking Peptide.