|The C-JUN jun (Catalog #MBS659384) is a Peptide and is intended for research purposes only. The product is available for immediate purchase. MyBioSource\'s c-Jun can be used in a range of immunoassay formats including, but not limited to, Western Blot (WB), Immunohistochemistry (IHC).
Suitable for use in Western Blotting, Immunohistochemistry.
Dilution: Western immunoblotting, add 10ul of antibody and 10ul of blocking peptide to 10ml of antibody dilution buffer.
Immunohistochemistry, add 2ul of antibody and 10ul of blocking peptide to 0.088ml of buffer. Researchers should empirically determine the suitability of the C-JUN jun for an application not listed in the data sheet. Researchers commonly develop new applications and it is an integral, important part of the investigative research process.
The C-JUN jun product has the following accession number(s) (GI #1911701) (NCBI Accession #AAB50808.1) (Uniprot Accession #P56432). Researchers may be interested in using Bioinformatics databases such as those available at The National Center for Biotechnology Information (NCBI) website for more information about accession numbers and the proteins they represent. Even researchers unfamiliar with bioinformatics databases will find the NCBI databases to be quite user friendly and useful.
To buy or view more detailed product information and pricing, please click on the technical datasheet page below:
c-Jun is a member of the Jun Family containing c-Jun, JunB and JunD, and is a component of the transcription factor AP-1 (activator protein-1). AP-1 is composed of dimers of Fos, Jun and ATF family members and binds to and activates transcription at TRE/AP-1 elements (Reviewed in 1).Extracellular signals including growth factors, chemokines and stress activate AP-1-dependent transcription. The transcriptional activity of c-Jun is regulated by phosphorylation at Ser63 and Ser73 through SAPK/JNK (reviewed in 2). Knock-out studies in mice have shown that c-Jun is essential for embryogenesis (3), and subsequent studies have demonstrated roles for c-Jun in various tissues and developmental processes including axon regeneration (4), liver regeneration (5) and T cell development (6).AP-1 regulated genes exert diverse biological functions including cell proliferation, differentiation, and apoptosis, as well as transformation, invasion and metastasis, depending on cell type and context (7-9). Other target genes regulate survival as well as hypoxia and angiogenesis (8,10). c-Jun has emerged as a promising therapeutic target for cancer, vascular remodeling, acute inflammation, as well as rheumatoid arthritis (11-13).
C-JUN also interacts with the following gene(s): EGF, FOS, HIF1A, IL12B, IL1B, IL6, IL8, MAPK10, MAPK9, TNF. The following patways have been known to be associated with this gene. Adipose Tissue, Brain, Embryonic Tissue, Intestine, Ovary, Thymus, Uterus tissues are correlated with this protein.