|The c-erbB proto-oncogene c-erbb proto-oncogene (Catalog #MBS474032) is a Peptide and is intended for research purposes only. The product is available for immediate purchase.
ELISA: 50 ng/well
Western Blot: 1:1,000. Researchers should empirically determine the suitability of the c-erbB proto-oncogene c-erbb proto-oncogene for an application not listed in the data sheet. Researchers commonly develop new applications and it is an integral, important part of the investigative research process.
The c-erbB proto-oncogene c-erbb proto-oncogene product has the following accession number(s) (GI #8815559) (NCBI Accession #AAB19486.2) (Uniprot Accession #Q9P2Z9). Researchers may be interested in using Bioinformatics databases such as those available at The National Center for Biotechnology Information (NCBI) website for more information about accession numbers and the proteins they represent. Even researchers unfamiliar with bioinformatics databases will find the NCBI databases to be quite user friendly and useful. The amino acid sequence is listed below:
Peptide Sequence: Phospho-EG FR (Ser-1142) synthetic peptide correspond ing to amino acid residues surroundin g serine 1142 of human EGFR (ErbB-1). This human EGFR sequence has high homology with rat and mouse EGFR, and is not conserved in other ErbB family members.
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The epidermal growth factor receptor (EGFR) is a transmembrane glycoprotein with an extracellular ligand-binding domain and a cytoplasmic domain with intrinsic tyrosine kinase activity. The cytoplasmic domain has a C-terminal region with multiple autophosphorylation sites (Tyr-992, 1068, 1086, 1148, and 1173). These sites are important for downstream signaling and rapid internalization. In addition, EGFR activation leads to c-Src mediated phosphorylation of Tyr-845 and Tyr-1101. The former site is required for mitogenic responses to EGFR activation, while the latter may be an SH2 binding site. Phosphorylation of EGFR on serine and threonine residues is thought to represent a mechanism for regulation of receptor kinase activity and internalization. These sites include a PKC site (Thr-654), CAMKII sites (Ser-1046, 1047, 1057, and 1142), and constitutively phosphorylated sites (Ser-967 and Ser-1002). Thus, the regulation of EGFR activity involves a complex series of phosphorylation events at multiple sites throughout the intracellular portion of the receptor.
The following patways have been known to be associated with this gene. c-erbB proto-oncogene also interacts with the following gene(s): FLNA.