BNIP3L blocking peptide product blog
Tags: Bnip3L; Blocking Peptide; NIX; BNIP3L blocking peptide;
The BNIP3L bnip3l (Catalog #MBS9218629) is a Blocking Peptide and is intended for research purposes only. The product is available for immediate purchase.The BNIP3L bnip3l product has the following accession number(s) (GI #6093509) (NCBI Accession #O60238.1) (Uniprot Accession #O60238). Researchers may be interested in using Bioinformatics databases such as those available at The National Center for Biotechnology Information (NCBI) website for more information about accession numbers and the proteins they represent. Even researchers unfamiliar with bioinformatics databases will find the NCBI databases to be quite user friendly and useful.
To buy or view more detailed product information and pricing, please click on the technical datasheet page below:
Induces apoptosis. Interacts with viral and cellular anti-apoptosis proteins. Can overcome the suppressors BCL-2 and BCL-XL, although high levels of BCL-XL expression will inhibit apoptosis. Inhibits apoptosis induced by BNIP3. Involved in mitochondrial quality control via its interaction with SPATA18/MIEAP: in response to mitochondrial damage, participates to mitochondrial protein catabolic process (also named MALM) leading to the degradation of damaged proteins inside mitochondria. The physical interaction of SPATA18/MIEAP, BNIP3 and BNIP3L/NIX at the mitochondrial outer membrane regulates the opening of a pore in the mitochondrial double membrane in order to mediate the translocation of lysosomal proteins from the cytoplasm to the mitochondrial matrix. May function as a tumor suppressor.
Cellular Location: Nucleus envelope. Endoplasmic reticulum. Mitochondrion outer membrane. Membrane; Single-pass membrane protein. Note: Colocalizes with SPATA18 at the mitochondrion outer membrane. BNIP3L also interacts with the following gene(s): BCL2, BNIP3, CREBBP, GABARAP, TP53. Blood, Brain, Embryonic Tissue, Heart, Kidney, Liver, Lung, Muscle, Prostate, Vascular tissues are correlated with this protein. The following patways have been known to be associated with this gene. Brain Diseases, Breast Neoplasms, Cardiomyopathies, Cardiovascular Diseases, Disease Models, Animal, Heart Diseases, Liver Diseases, Necrosis, Neoplasm Metastasis, Nervous System Diseases are some of the diseases may be linked to NIX Antibody (Center) Blocking peptide.