BIRC7 blocking peptide product blog
Tags: BIRC7; Blocking Peptide; BIRC7 blocking peptide;
The BIRC7 birc7 (Catalog #MBS9225902) is a Blocking Peptide and is intended for research purposes only. The product is available for immediate purchase.The BIRC7 birc7 product has the following accession number(s) (GI #21759008) (NCBI Accession #Q96CA5.2) (Uniprot Accession #Q96CA5). Researchers may be interested in using Bioinformatics databases such as those available at The National Center for Biotechnology Information (NCBI) website for more information about accession numbers and the proteins they represent. Even researchers unfamiliar with bioinformatics databases will find the NCBI databases to be quite user friendly and useful.
To buy or view more detailed product information and pricing, please click on the technical datasheet page below:
Apoptotic regulator capable of exerting proapoptotic and anti-apoptotic activities and plays crucial roles in apoptosis, cell proliferation, and cell cycle control. Its anti-apoptotic activity is mediated through the inhibition of CASP3, CASP7 and CASP9, as well as by its E3 ubiquitin-protein ligase activity. As it is a weak caspase inhibitor, its anti-apoptotic activity is thought to be due to its ability to ubiquitinate DIABLO/SMAC targeting it for degradation thereby promoting cell survival. May contribute to caspase inhibition, by blocking the ability of DIABLO/SMAC to disrupt XIAP/BIRC4-caspase interactions. Protects against apoptosis induced by TNF or by chemical agents such as adriamycin, etoposide or staurosporine. Suppression of apoptosis is mediated by activation of MAPK8/JNK1, and possibly also of MAPK9/JNK2. This activation depends on TAB1 and NR2C2/TAK1. In vitro, inhibits CASP3 and proteolytic activation of pro-CASP9. Isoform 1 blocks staurosporine-induced apoptosis. Isoform 2 blocks etoposide-induced apoptosis. Isoform 2 protects against natural killer (NK) cell killing whereas isoform 1 augments killing.
Cellular Location: Nucleus. Cytoplasm. Golgi apparatus. Note: Nuclear, and in a filamentous pattern throughout the cytoplasm. Full-length livin is detected exclusively in the cytoplasm, whereas the truncated form (tLivin) is found in the peri-nuclear region with marked localization to the Golgi apparatus; the accumulation of tLivin in the nucleus shows positive correlation with the increase in apoptosis. Tissue Location: Isoform 1 and isoform 2 are expressed at very low levels or not detectable in most adult tissues. Detected in adult heart, placenta, lung, lymph node, spleen and ovary, and in several carcinoma cell lines. Isoform 2 is detected in fetal kidney, heart and spleen, and at lower levels in adult brain, skeletal muscle and peripheral blood leukocytes. Adenocarcinoma, Carcinoma, Carcinoma, Non-Small-Cell Lung, Carcinoma, Squamous Cell, Lung Neoplasms, Necrosis, Neoplasm Invasiveness, Neoplasm Metastasis, Neoplasms, Experimental, Urinary Bladder Neoplasms are some of the diseases may be linked to BIRC7 Antibody (C-term) Blocking Peptide. BIRC7 also interacts with the following gene(s): BIRC2, BIRC5, CASP3, CASP7, CASP9, DIABLO, MITF, UBE2D2. Embryonic Tissue, Eye, Intestine, Liver, Lung, Mixed, Placenta, Skin tissues are correlated with this protein. The following patways have been known to be associated with this gene.