|The BECN1 becn1 (Catalog #MBS9223222) is a Blocking Peptide and is intended for research purposes only. The product is available for immediate purchase.
The BECN1 becn1 product has the following accession number(s) (GI #13124704) (NCBI Accession #Q14457.2) (Uniprot Accession #Q14457). Researchers may be interested in using Bioinformatics databases such as those available at The National Center for Biotechnology Information (NCBI) website for more information about accession numbers and the proteins they represent. Even researchers unfamiliar with bioinformatics databases will find the NCBI databases to be quite user friendly and useful.
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Plays a central role in autophagy (PubMed:23184933). Required for the abcission step in cytokinesis (PubMed:20208530). Protects against infection by a neurovirulent strain of Sindbis virus (PubMed:9765397). May play a role in antiviral host defense.
Cellular Location: Golgi apparatus, trans-Golgi network membrane; Peripheral membrane protein. Note: Interaction with ATG14 promotes translocation to autophagosomes. Expressed in dendrites and cell bodies of cerebellar Purkinje cells (By similarity). Tissue Location: Ubiquitous. Blood, Brain, Heart, Kidney, Liver, Lung, Lymph, Muscle, Nerve, Vascular tissues are correlated with this protein. Brain Diseases, Carcinoma, Hepatocellular, Cardiovascular Diseases, Heart Diseases, Inflammation, Liver Diseases, Lung Diseases, Lung Neoplasms, Necrosis, Nervous System Diseases are some of the diseases may be linked to Beclin 1 Antibody Blocking peptide. The following patways have been known to be associated with this gene. BECN1 also interacts with the following gene(s): AMBRA1, ATG14, BCL2, BCL2L1, MCL1, PARK2, PIK3C3, PIK3R4, UVRAG.