|The BACE1 bace1 (Catalog #MBS9227243) is a Blocking Peptide and is intended for research purposes only. The product is available for immediate purchase.
The BACE1 bace1 product has the following accession number(s) (GI #296434407) (NCBI Accession #P56817.2) (Uniprot Accession #P56817). Researchers may be interested in using Bioinformatics databases such as those available at The National Center for Biotechnology Information (NCBI) website for more information about accession numbers and the proteins they represent. Even researchers unfamiliar with bioinformatics databases will find the NCBI databases to be quite user friendly and useful.
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Responsible for the proteolytic processing of the amyloid precursor protein (APP). Cleaves at the N-terminus of the A-beta peptide sequence, between residues 671 and 672 of APP, leads to the generation and extracellular release of beta-cleaved soluble APP, and a corresponding cell-associated C-terminal fragment which is later released by gamma-secretase.
Cellular Location: Membrane; Single-pass type I membrane protein. Golgi apparatus, trans-Golgi network. Endoplasmic reticulum. Endosome. Cell surface. Cytoplasmic vesicle membrane Note: Predominantly localized to the later Golgi/trans-Golgi network (TGN) and minimally detectable in the early Golgi compartments. A small portion is also found in the endoplasmic reticulum, endosomes and on the cell surface. Tissue Location: Expressed at high levels in the brain and pancreas. In the brain, expression is highest in the substantia nigra, locus coruleus and medulla oblongata. Alzheimer Disease, Brain Diseases, Cognition Disorders, Disease Models, Animal, Inflammation, Learning Disorders, Memory Disorders, Necrosis, Nerve Degeneration, Neurobehavioral Manifestations are some of the diseases may be linked to BACE1 Antibody (N-term) Blocking Peptide. Blood, Brain, Ear, Embryonic Tissue, Eye, Kidney, Liver, Muscle, Ovary, Vascular tissues are correlated with this protein. The following patways have been known to be associated with this gene. BACE1 also interacts with the following gene(s): APP, FURIN, GGA1, ITM2B, LRP1, NCSTN, PLSCR1, PSEN1, RANBP9, SORL1.