AXIN1 blocking peptide product blog
Tags: AXIN1; Blocking Peptide; AXIN1 blocking peptide;
The AXIN1 axin1 (Catalog #MBS9222363) is a Blocking Peptide and is intended for research purposes only. The product is available for immediate purchase.The AXIN1 axin1 product has the following accession number(s) (GI #20532378) (NCBI Accession #O15169.2) (Uniprot Accession #O15169). Researchers may be interested in using Bioinformatics databases such as those available at The National Center for Biotechnology Information (NCBI) website for more information about accession numbers and the proteins they represent. Even researchers unfamiliar with bioinformatics databases will find the NCBI databases to be quite user friendly and useful.
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Component of the beta-catenin destruction complex required for regulating CTNNB1 levels through phosphorylation and ubiquitination, and modulating Wnt-signaling. Controls dorsoventral patterning via two opposing effects; down-regulates CTNNB1 to inhibit the Wnt signaling pathway and ventralize embryos, but also dorsalizes embryos by activating a Wnt- independent JNK signaling pathway. In Wnt signaling, probably facilitates the phosphorylation of CTNNB1 and APC by GSK3B. Likely to function as a tumor suppressor. Facilitates the phosphorylation of TP53 by HIPK2 upon ultraviolet irradiation. Enhances TGF-beta signaling by recruiting the RNF111 E3 ubiquitin ligase and promoting the degradation of inhibitory SMAD7. Also component of the AXIN1-HIPK2-TP53 complex which controls cell growth, apoptosis and development.
Cellular Location: Cytoplasm. Nucleus. Membrane. Cell membrane. Note: MACF1 is required for its translocation to cell membrane (By similarity). On UV irradiation, translocates to the nucleus and colocalizes with DAAX. Tissue Location: Ubiquitously expressed. The following patways have been known to be associated with this gene. Blood, Bone, Brain, Embryonic Tissue, Eye, Liver, Lung, Mouth, Muscle, Prostate tissues are correlated with this protein. AXIN1 also interacts with the following gene(s): APC, CSNK1E, CTNNB1, DVL1, GSK3B, LRP5, LRP6. Brain Diseases, Carcinoma, Hepatocellular, Disease Models, Animal, Heart Diseases, Hyperplasia, Liver Diseases, Musculoskeletal Diseases, Neoplasms, Experimental, Nervous System Diseases, Ovarian Neoplasms are some of the diseases may be linked to AXIN1 Antibody (Center) Blocking Peptide.