|The ATF7 atf7 (Catalog #MBS9227882) is a Blocking Peptide and is intended for research purposes only. The product is available for immediate purchase.
The ATF7 atf7 product has the following accession number(s) (GI #12643393) (NCBI Accession #P17544.2) (Uniprot Accession #P17544). Researchers may be interested in using Bioinformatics databases such as those available at The National Center for Biotechnology Information (NCBI) website for more information about accession numbers and the proteins they represent. Even researchers unfamiliar with bioinformatics databases will find the NCBI databases to be quite user friendly and useful.
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Plays important functions in early cell signaling. Binds the cAMP response element (CRE) (consensus: 5\'-GTGACGT[AG][AG]- 3\'), a sequence present in many viral and cellular promoters. Activator of the NF-ELAM1/delta-A site of the E-selectin promoter. Has no intrinsic transcriptional activity, but activates transcription on formation of JUN or FOS heterodimers. Also can bind TRE promoter sequences when heterodimerized with members of the JUN family. Isoform 5/ATF-4 acts as a negative regulator, inhibiting both ATF2 and ATF7 transcriptional activities. It may exert these effects by sequestrating in the cytoplasm the Thr-53 phosphorylating kinase, preventing activation.
Cellular Location: Nucleus. Nucleus, nucleoplasm. Note: Mainly nucleoplasmic. Restricted distribution to the perinuculear region The sumoylated form locates to the nuclear periphery. Tissue Location: Expressed in heart, lung and skeletal muscle. Isoform 4 is expressed in various tissues including heart, brain, placenta, lung and skeletal muscle. Highest levels in skeletal muscle. Lowest in lung and placenta. ATF7 also interacts with the following gene(s): FOS, MAPK8, PTP4A1, TAF12. The following patways have been known to be associated with this gene. Brain Diseases, Cell Transformation, Neoplastic, Necrosis, Neoplasm Metastasis, Nervous System Diseases are some of the diseases may be linked to ATF7 Antibody (N-term) Blocking Peptide. Blood, Bone, Bone Marrow, Heart, Liver, Lung, Lymph Node tissues are correlated with this protein.