|The ASIC3 asic3 (Catalog #MBS9224036) is a Blocking Peptide and is intended for research purposes only. The product is available for immediate purchase.
The ASIC3 asic3 product has the following accession number(s) (GI #82582992) (NCBI Accession #Q9UHC3.2) (Uniprot Accession #Q9UHC3). Researchers may be interested in using Bioinformatics databases such as those available at The National Center for Biotechnology Information (NCBI) website for more information about accession numbers and the proteins they represent. Even researchers unfamiliar with bioinformatics databases will find the NCBI databases to be quite user friendly and useful.
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Cation channel with high affinity for sodium, which is gated by extracellular protons and inhibited by the diuretic amiloride. Generates a biphasic current with a fast inactivating and a slow sustained phase. In sensory neurons is proposed to mediate the pain induced by acidosis that occurs in ischemic, damaged or inflamed tissue. May be involved in hyperalgesia. May play a role in mechanoreception. Heteromeric channel assembly seems to modulate channel properties.
Cellular Location: Cell membrane; Multi-pass membrane protein. Cytoplasm. Note: Cell surface expression may be stabilized by interaction with LIN7B and cytoplasmic retention by interaction with DLG4. In part cytoplasmic in cochlea cells (By similarity). Tissue Location: Expressed by sensory neurons. Strongly expressed in brain, spinal chord, lung, lymph nodes, kidney, pituitary, heart and testis. The following patways have been known to be associated with this gene. Acidosis, Arthritis, Cardiovascular Diseases, Drug Hypersensitivity, Fibrosis, Heart Diseases, Hyperalgesia, Inflammation, Pain, Stroke are some of the diseases may be linked to ACCN3 Antibody (N-term) Blocking Peptide. ASIC3 also interacts with the following gene(s): CFTR, DLG4, LIN7B, PICK1, TRPV1. Blood, Brain, Embryonic Tissue, Eye, Lung, Muscle, Ovary, Skin, Testis, Uterus tissues are correlated with this protein.