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Apicidin antibiotic product blog

Posted on 2015-12-29 08:27:58 by mybiosource_staff
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Tags: Antibiotic; Apicidin; Apicidin antibiotic;
The Apicidin n/a (Catalog #MBS651532) is an Antibiotic produced from Fusarium sp. and is intended for research purposes only. The product is available for immediate purchase.
Suitable for use as a histone deacetylase inhibitor. Other applications have not been tested. Researchers should empirically determine the suitability of the Apicidin n/a for an application not listed in the data sheet. Researchers commonly develop new applications and it is an integral, important part of the investigative research process.

The Apicidin n/a product has the following accession number(s) (GI #270269268) (NCBI Accession #ACZ66258.1). Researchers may be interested in using Bioinformatics databases such as those available at The National Center for Biotechnology Information (NCBI) website for more information about accession numbers and the proteins they represent. Even researchers unfamiliar with bioinformatics databases will find the NCBI databases to be quite user friendly and useful.

To buy or view more detailed product information and pricing, please click on the technical datasheet page below:

Apicidin is a cyclic peptide antibiotic with broad spectrum antiparasitic and antiprotozoan activity. Apicidin, a histone deacetylase inhibitor, is anti-angiogenic and induces apoptosis. A potent, cell permeable inhibitor of histone deacetylase (IC50 = 700 pM for parasitic histone deacetylase). Inhibits HeLa cell proliferation (IC50 = 50 - 100 nM) and induces the transcriptional activation of p21 (WAF1) in a reversible manner. Also prevents H-ras-induced invasive phenotype of MCF-10A cells possibly by down regulating MMP-2 in a reversible manner. Apicidin has antiproliferative activity on HeLa cells accompanied by cell arrest at the G1 phase. Apicidin induces selective changes in the expression of p21 and gelsolin.

Apicidin n/a

CAS Number: 183506-66-3
Molecular Formula: C34H49N5O6. Solubility: Reconstitute in DMSO or ethanol (~50mg/ml).
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