anti-TYR antibody product blog
Tags: Antibody; Polyclonal Antibody; anti-TYR antibody; TYR;
The TYR n/a (Catalog #MBS627694) is an Antibody produced from Rabbit and is intended for research purposes only. The product is available for immediate purchase. The TYR, ID (Tyrosinase, Monophenol Monooxygenase, Tumor Rejection Antigen AB, SK29-AB, LB24-AB) reacts with Human and may cross-react with other species as described in the data sheet. MyBioSource\'s TYR can be used in a range of immunoassay formats including, but not limited to, ELISA (EL/EIA), Western Blot (WB), Immunohistochemistry (IHC), Immunofluorescence (IF).Suitable for use in ELISA, Western Blot, Immunohistochemistry and Immunofluorescence. Researchers should empirically determine the suitability of the TYR n/a for an application not listed in the data sheet. Researchers commonly develop new applications and it is an integral, important part of the investigative research process.
The TYR n/a product has the following accession number(s) (GI #329025995). Researchers may be interested in using Bioinformatics databases such as those available at The National Center for Biotechnology Information (NCBI) website for more information about accession numbers and the proteins they represent. Even researchers unfamiliar with bioinformatics databases will find the NCBI databases to be quite user friendly and useful.
To buy or view more detailed product information and pricing, please click on the technical datasheet page below:
Please refer to the product datasheet for known applications of a given antibody. We\'ve tested the TYR, ID (Tyrosinase, Monophenol Monooxygenase, Tumor Rejection Antigen AB, SK29-AB, LB24-AB) with the following immunoassay(s):
Western Blot (WB) (Western blot analysis of Tyrosinase Antibody (Center) in A375, 293 cell line lysates (35ug/lane). Tyrosinase (arrow) was detected using the purified Pab.)
Immunofluorescence (IF) (Confocal immunofluorescent analysis of TYR Antibody (Center) with HepG2 cell followed by Alexa Fluor 488-conjugated goat anti-rabbit lgG (green).DAPI was used to stain the cell nuclear (blue).)
Immunohistochemistry (IHC) (TYR Antibody (Center) (AP7345c)immunohistochemistry analysis in formalin fixed and paraffin embedded human melanoma followed by peroxidase conjugation of the secondary antibody and DAB staining.This data demonstrates the use of TYR Antibody (Center) for immunohistochemistry. Clinical relevance has not been evaluated.)
TYR catalyzes the first 2 steps, and at least 1 subsequent step, in the conversion of tyrosine to melanin. The protein has both tyrosine hydroxylase and dopa oxidase catalytic activities, and requires copper for function. Mutations in this protein result in oculocutaneous albinism, and nonpathologic polymorphisms result in skin pigmentation variation.
Immunogen: Synthetic peptide corresponding to aa183-213 from the center region of human Tyrosinase conjugated to KLH. Cellular Localization: Melanosome membrane; single-pass, type 1 membranre protein
Cellular Localization: Melanosome membrane; single-pass, type 1 membranre protein. In general, we may offer more than one antibody to a given target to enable options for the researcher. Available antibodies recognizing TYR are readily searchable from our website. Different antibodies against the same target such as TYR may be optimized or tested for different applications and species. This enables researchers to select the option that may be best for their model system, to screen more than antibody to determine which one may be best for their model system, as well as to use more than one antibody to follow up on and validate their results.