anti-TXNIP antibody product blog
Tags: Antibody; Polyclonal Antibody; TXNIP; anti-TXNIP antibody;
The TXNIP txnip (Catalog #MBS6012043) is an Antibody produced from Rabbit and is intended for research purposes only. The product is available for immediate purchase. The TXNIP, NT (TXNIP, VDUP1, Thioredoxin-interacting protein, Thioredoxin-binding protein 2, Vitamin D3 up-regulated protein 1) reacts with Human and may cross-react with other species as described in the data sheet. MyBioSource\'s TXNIP can be used in a range of immunoassay formats including, but not limited to, ELISA (EL/EIA), Western Blot (WB).Suitable for use in Western Blot, ELISA
Dilution: ELISA: 1:1,000
Western Blot: 1:100-500. Researchers should empirically determine the suitability of the TXNIP txnip for an application not listed in the data sheet. Researchers commonly develop new applications and it is an integral, important part of the investigative research process.
The TXNIP txnip product has the following accession number(s) (GI #171184421) (NCBI Accession #NP_006463.3) (Uniprot Accession #Q9H3M7). Researchers may be interested in using Bioinformatics databases such as those available at The National Center for Biotechnology Information (NCBI) website for more information about accession numbers and the proteins they represent. Even researchers unfamiliar with bioinformatics databases will find the NCBI databases to be quite user friendly and useful.
To buy or view more detailed product information and pricing, please click on the technical datasheet page below:
Please refer to the product datasheet for known applications of a given antibody. We\'ve tested the TXNIP, NT (TXNIP, VDUP1, Thioredoxin-interacting protein, Thioredoxin-binding protein 2, Vitamin D3 up-regulated protein 1) with the following immunoassay(s):
Western Blot (WB) (TXNIP Antibody (N-term) western blot analysis in NCI-H292 cell line lysates (35ug/lane).This demonstrates the TXNIP antibody detected the TXNIP protein (arrow).)
TXNIP may act as an oxidative stress mediator by inhibiting thioredoxin activity or by limiting its bioavailability. Interacts with COPS5 and restores COPS5-induced suppression of CDKN1B stability, blocking the COPS5-mediated translocation of CDKN1B from the nucleus to the cytoplasm. Functions as a transcriptional repressor, possibly by acting as a bridge molecule between transcription factors and corepressor complexes, and over-expression will induce G0/G1 cell cycle arrest. Required for the maturation of natural killer cells.
Immunogen: TXNIP antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 1-30 amino acids from the N-terminal region of human TXNIP. In general, we may offer more than one antibody to a given target to enable options for the researcher. Available antibodies recognizing TXNIP are readily searchable from our website. Different antibodies against the same target such as TXNIP may be optimized or tested for different applications and species. This enables researchers to select the option that may be best for their model system, to screen more than antibody to determine which one may be best for their model system, as well as to use more than one antibody to follow up on and validate their results. TXNIP also interacts with the following gene(s): BCL6, HDAC10, IL2RB, INS, KISS1, MLXIPL, NLRP3, TXN. The following patways have been known to be associated with this gene.