|The TSLP tslp (Catalog #MBS535699) is an Antibody produced from Rabbit and is intended for research purposes only. The product is available for immediate purchase. The TSLP antibody reacts with Human TSLP and may cross-react with other species as described in the data sheet. MyBioSource\'s TSLP can be used in a range of immunoassay formats including, but not limited to, ELISA (EIA), Inhibition, Western Blot (WB). Researchers should empirically determine the suitability of the TSLP tslp for an application not listed in the data sheet. Researchers commonly develop new applications and it is an integral, important part of the investigative research process.
The TSLP tslp product has the following accession number(s) (GI #14719428) (NCBI Accession #NP_149024.1) (Uniprot Accession #Q969D9). Researchers may be interested in using Bioinformatics databases such as those available at The National Center for Biotechnology Information (NCBI) website for more information about accession numbers and the proteins they represent. Even researchers unfamiliar with bioinformatics databases will find the NCBI databases to be quite user friendly and useful.
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Affinity purified Rabbit polyclonal TSLP antibody.
Biological Significance: TSLP is a hemopoietic protein that is expressed in the heart, liver and prostate. TSLP overlaps biological activities with IL7 and binds with the heterodimeric receptor complex consisting of the IL7R alpha chain (IL7Ra) and the TSLP-specific chain (TSLPR). Like IL7, TSLP induces phosphorylation of STAT3 and STAT5, but uses kinases other than the JAKs for activation. TSLP prohibited apoptosis and stimulated growth of the human acute myeloid leukemia (AML)-derived cell line MUTZ3. Immunogen: TSLP antibody was raised in rabbit using highly pure recombinant human TSLP as the immunogen. In general, we may offer more than one antibody to a given target to enable options for the researcher. Available antibodies recognizing TSLP are readily searchable from our website. Different antibodies against the same target such as TSLP may be optimized or tested for different applications and species. This enables researchers to select the option that may be best for their model system, to screen more than antibody to determine which one may be best for their model system, as well as to use more than one antibody to follow up on and validate their results. The following patways have been known to be associated with this gene. TSLP also interacts with the following gene(s): CCL17, CRLF2, FOXP3, IL13, IL4, IL7R, STAT5A, STAT5B, TNFRSF4. Bone Marrow, Brain, Connective Tissue, Eye, Lung, Salivary Gland, Skin, Thyroid tissues are correlated with this protein. Asthma, Cardiovascular Diseases, Dermatitis, Atopic, Disease Models, Animal, Eosinophilic Esophagitis, Fibrosis, Hyperplasia, Inflammation, Lung Diseases, Necrosis are some of the diseases may be linked to TSLP antibody.