anti-TPSB2 antibody product blog
Tags: Antibody; Monoclonal Antibody; Tryptase, beta2; anti-TPSB2 antibody; TPSB2;
The TPSB2 tpsb2 (Catalog #MBS602997) is an Antibody produced from Rat and is intended for research purposes only. The product is available for immediate purchase. The Tryptase, beta2 (TPSB2, MCPT6, Mast Cell Protease 6) reacts with Mouse and may cross-react with other species as described in the data sheet. MyBioSource\'s Tryptase, beta2 can be used in a range of immunoassay formats including, but not limited to, ELISA (EL/EIA), Immunoprecipitation (IP), Neutralization.Suitable for use in Immunoprecipitation, ELISA and Neutralization.
Dilution: Immunoprecipitation: 25ug/ml immunoprecipitates recombinant mouse Tryptase, beta 2 from conditioned cell culture medium.
Neutralization: Measured by its ability to neutralize Recombinant Mouse Mast Cell Protease6/Mcpt6 (1ug/ml) cleavage of the fluorogenic peptide substrate Mca-RPKPVE-Nval-WRK(Dnp)-NH2 (10uM). The Neutralization Dose (ND50) is typically 3ug/ml. Researchers should empirically determine the suitability of the TPSB2 tpsb2 for an application not listed in the data sheet. Researchers commonly develop new applications and it is an integral, important part of the investigative research process.
The TPSB2 tpsb2 product has the following accession number(s) (GI #68508970) (NCBI Accession #NP_077078.5) (Uniprot Accession #P20231). Researchers may be interested in using Bioinformatics databases such as those available at The National Center for Biotechnology Information (NCBI) website for more information about accession numbers and the proteins they represent. Even researchers unfamiliar with bioinformatics databases will find the NCBI databases to be quite user friendly and useful.
To buy or view more detailed product information and pricing, please click on the technical datasheet page below:
As major neutral proteases present in the mast cells, tryptases function as mediators in the pathogenesis of asthema and other allergic and inflammatory disorders. Tryptase, beta2 (TPSB2) consists of a signal peptide (residues 1 to 21), a pro peptide (residues 22 to 31) and a mature chain (residues 32 to 275). The amino acid sequence of mouse TPSB2 is 88%, 78%, 76%, and 73% identical to that of mouse, human (TPSB2 and TPSAB1), chimpanzee, and canine.
Immunogen: Recombinant protein corresponding to aa32-276 from mouse Tryptase, beta2 expressed in NSO cells (P21845). In general, we may offer more than one antibody to a given target to enable options for the researcher. Available antibodies recognizing TPSB2 are readily searchable from our website. Different antibodies against the same target such as TPSB2 may be optimized or tested for different applications and species. This enables researchers to select the option that may be best for their model system, to screen more than antibody to determine which one may be best for their model system, as well as to use more than one antibody to follow up on and validate their results. Bone, Connective Tissue, Intestine, Kidney, Liver, Lung, Lymph Node, Nerve, Stomach, Uterus tissues are correlated with this protein. Inflammation are some of the diseases may be linked to Tryptase, beta2 (TPSB2, MCPT6, Mast Cell Protease 6).