|The TOLLIP tollip (Catalog #MBS150403) is an Antibody produced from Rabbit and is intended for research purposes only. The product is available for immediate purchase. The TOLLIP Antibody reacts with Human, Mouse, Rat and may cross-react with other species as described in the data sheet. MyBioSource\'s TOLLIP can be used in a range of immunoassay formats including, but not limited to, ELISA (EIA), Western Blot (WB), Immunocytochemistry (ICC).
TOLLIP antibody can be used for the detection of TOLLIP by Western blot at 0.5 - 2 mug/mL. Antibody can also be used for immunocytochemistry starting at 2 mug/mL. Researchers should empirically determine the suitability of the TOLLIP tollip for an application not listed in the data sheet. Researchers commonly develop new applications and it is an integral, important part of the investigative research process.
The TOLLIP tollip product has the following accession number(s) (GI #17390641) (NCBI Accession #AAH18272) (Uniprot Accession #Q9H0E2). Researchers may be interested in using Bioinformatics databases such as those available at The National Center for Biotechnology Information (NCBI) website for more information about accession numbers and the proteins they represent. Even researchers unfamiliar with bioinformatics databases will find the NCBI databases to be quite user friendly and useful.
To buy or view more detailed product information and pricing, please click on the technical datasheet page below:
Please refer to the product datasheet for known applications of a given antibody. We\'ve tested the TOLLIP Antibody with the following immunoassay(s):
Western Blot (WB) (Western blot analysis of TOLLIP in rat brain cell lysate with TOLLIP antibody at (A) 0.5, (B) 1 and (C) 2μg/mL.)
Immunocytochemistry (ICC) (Immunocytochemistry of TOLLIP in THP-1 cells with TOLLIP antibody at 2 μg/mL.)
TOLLIP Antibody: Toll-like receptors (TLRs) are evolutionarily conserved pattern-recognition molecules resembling the toll proteins that mediate antimicrobial responses in Drosophila. These proteins recognize different microbial products during infection and serve as an important link between the innate and adaptive immune responses. The TLRs act through adaptor molecules to activate various kinases and transcription factors so the organism can respond to potential infection. These adaptor molecules include TOLLIP, MyD88, and TRIF. TOLLIP associates directly with TLR2 and TLR 4, acting as an inhibitor to TLR activation. This negative regulation of TLR signaling may serve to limit the production of proinflammatory mediators during infection and inflammation.
Immunogen: TOLLIP antibody was raised against a 16 amino acid synthetic peptide from near the center of human TOLLIP.
Buffer: TOLLIP Antibody is supplied in PBS containing 0.02% sodium azide. In general, we may offer more than one antibody to a given target to enable options for the researcher. Available antibodies recognizing TOLLIP are readily searchable from our website. Different antibodies against the same target such as TOLLIP may be optimized or tested for different applications and species. This enables researchers to select the option that may be best for their model system, to screen more than antibody to determine which one may be best for their model system, as well as to use more than one antibody to follow up on and validate their results.