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anti-TNFRSF10C antibody product blog

Posted on 2014-08-03 08:08:01 by mybiosource_staff
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Tags: Antibody; Polyclonal Antibody; DcR1; anti-TNFRSF10C antibody; TNFRSF10C;
The TNFRSF10C tnfrsf10c (Catalog #MBS150161) is an Antibody produced from Rabbit and is intended for research purposes only. The product is available for immediate purchase. The DcR1 Antibody reacts with Human, Mouse, Rat and may cross-react with other species as described in the data sheet. MyBioSource\'s DcR1 can be used in a range of immunoassay formats including, but not limited to, ELISA (EIA), Western Blot (WB), Immunocytochemistry (ICC), Immunofluorescence (IF).
DcR1 antibody can be used for detection of DcR1 by Western blot 0.5 mug/mL. An approximate 65 kDa band can be detected. Antibody can also be used for immunocytochemistry starting at 10 mug/mL. For immunofluorescence start at 20 mug/mL. Researchers should empirically determine the suitability of the TNFRSF10C tnfrsf10c for an application not listed in the data sheet. Researchers commonly develop new applications and it is an integral, important part of the investigative research process.

The TNFRSF10C tnfrsf10c product has the following accession number(s) (GI #2338421) (NCBI Accession #AF012536) (Uniprot Accession #O14798). Researchers may be interested in using Bioinformatics databases such as those available at The National Center for Biotechnology Information (NCBI) website for more information about accession numbers and the proteins they represent. Even researchers unfamiliar with bioinformatics databases will find the NCBI databases to be quite user friendly and useful.

To buy or view more detailed product information and pricing, please click on the technical datasheet page below:

Please refer to the product datasheet for known applications of a given antibody. We\'ve tested the DcR1 Antibody with the following immunoassay(s):
Western Blot (WB) (Western blot analysis of DcR1 in HeLa whole cell lysate with DcR1 antibody (ED) at 1:500 dilution.)
Western Blot (WB) TNFRSF10C.

Immunocytochemistry (ICC) (Immunocytochemistry of DcR1 in HeLa cells with DcR1 antibody at 10 μg/mL.)
Immunocytochemistry (ICC) TNFRSF10C.

Immunofluorescence (IF) (Immunofluorescence of DcR1 in Hela cells with DcR1 antibody at 20 μg/mL.)
Immunofluorescence (IF) TNFRSF10C.

DcR1 Antibody: Apoptosis is induced by certain cytokines including TNF and Fas ligand in the TNF family through their death domain containing receptors. TRAIL/Apo2L is a new member of the TNF family and induces apoptosis of a variety of tumor cell lines. DR4 and DR5 are the recently identified functional receptors for TRAIL. Two decoy receptors for TRAIL have been identified and designated DcR1/TRID/TRAIL-R3/LIT and DcR2/TRAIL-R4/TRUNDD. DcR1 has extracellular TRAIL-binding domain but lacks intracellular signaling domain. It is a glycophospholipid-anchored cell surface protein. DcR1 transcripts were expressed in many normal human tissues but not in most cancer cell lines. Overexpression of DcR1 did not induce apoptosis, but attenuated TRAIL-induced apoptosis.

Conjugate: Unconjugated
Immunogen: DcR1 antibody was raised against a peptide corresponding to amino acids in an extracellular domain of human DcR1 precursor.
Buffer: DcR1 Antibody is supplied in PBS containing 0.02% sodium azide. In general, we may offer more than one antibody to a given target to enable options for the researcher. Available antibodies recognizing TNFRSF10C are readily searchable from our website. Different antibodies against the same target such as TNFRSF10C may be optimized or tested for different applications and species. This enables researchers to select the option that may be best for their model system, to screen more than antibody to determine which one may be best for their model system, as well as to use more than one antibody to follow up on and validate their results.
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