|The TNFRSF10B tnfrsf10b (Catalog #MBS194074) is an Antibody produced from Rabbit and is intended for research purposes only. The product is available for immediate purchase. MyBioSource\'s DR5 can be used in a range of immunoassay formats including, but not limited to, Immunoblot.
Immunoblotting : use at 1:500-1:1,000 dilution.
Positive control: Whole cell lysate from HeLa cells or K562 cells. Researchers should empirically determine the suitability of the TNFRSF10B tnfrsf10b for an application not listed in the data sheet. Researchers commonly develop new applications and it is an integral, important part of the investigative research process.
The TNFRSF10B tnfrsf10b product has the following accession number(s) (GI #3721878) (Uniprot Accession #O14763). Researchers may be interested in using Bioinformatics databases such as those available at The National Center for Biotechnology Information (NCBI) website for more information about accession numbers and the proteins they represent. Even researchers unfamiliar with bioinformatics databases will find the NCBI databases to be quite user friendly and useful.
To buy or view more detailed product information and pricing, please click on the technical datasheet page below:
Apoptosis is induced by certain cytokines including TNF and Fas ligand in the TNF family through their death domain-containing receptors. TRAIL/Apo2L is a new member of the TNF family. A novel death domaincontaining receptor for TRAIL was recently identified and designated DR5, Apo2, TRAIL-R2, TRICK2, or KILLER by several independent laboratories. Like DR4, DR5 transcript is widely expressed in normal tissues and in many types of tumor cells. DR5 binds to TRAIL and mediates TRAIL-induced cell death. Overexpression of DR5 induces apoptosis and activates NF- kappa B.
Antigen: Peptide corresponding to aa388-407 of human DR5 precursor. Stabilizer: None
Preservatives: 0.02% sodium azide.
Dilutions Instructions: Dilute in PBS or medium which is identical to that used in the assay system. In general, we may offer more than one antibody to a given target to enable options for the researcher. Available antibodies recognizing TNFRSF10B are readily searchable from our website. Different antibodies against the same target such as TNFRSF10B may be optimized or tested for different applications and species. This enables researchers to select the option that may be best for their model system, to screen more than antibody to determine which one may be best for their model system, as well as to use more than one antibody to follow up on and validate their results. The following patways have been known to be associated with this gene. Adenocarcinoma, Breast Neoplasms, Carcinoma, Colorectal Neoplasms, Drug Toxicity, Leukemia, Liver Diseases, Neoplasms, Neoplasms, Experimental, Skin Diseases are some of the diseases may be linked to Anti-DR5 Antibody. TNFRSF10B also interacts with the following gene(s): CASP8, CFLAR, FADD, TNFRSF10A, TNFSF10. Blood, Bone Marrow, Brain, Kidney, Liver, Lung, Muscle, Prostate, Skin, Vascular tissues are correlated with this protein.