|The TICAM2 ticam2 (Catalog #MBS540667) is an Antibody produced from Rabbit and is intended for research purposes only. The product is available for immediate purchase. The TICAM2 Antibody Affinity Purified reacts with Cat, Human, Monkey, Pig and may cross-react with other species as described in the data sheet. MyBioSource\'s TICAM2 can be used in a range of immunoassay formats including, but not limited to, ELISA (EIA), Western Blot (WB).
Dot Blot: 1:10,000
Western Blot: 1:250. Researchers should empirically determine the suitability of the TICAM2 ticam2 for an application not listed in the data sheet. Researchers commonly develop new applications and it is an integral, important part of the investigative research process.
The TICAM2 ticam2 product has the following accession number(s) (GI #37677661) (NCBI Accession #AAQ97430.1) (Uniprot Accession #Q86XR7). Researchers may be interested in using Bioinformatics databases such as those available at The National Center for Biotechnology Information (NCBI) website for more information about accession numbers and the proteins they represent. Even researchers unfamiliar with bioinformatics databases will find the NCBI databases to be quite user friendly and useful.
To buy or view more detailed product information and pricing, please click on the technical datasheet page below:
Please refer to the product datasheet for known applications of a given antibody. We\'ve tested the TICAM2 Antibody Affinity Purified with the following immunoassay(s):
Western Blot (WB)
Affinity Purified TIRAP3b long form Antibody
Functions as sorting adapter in LPS-TLR4 signaling to regulate the MYD88-independent pathway during the innate immune response to LPS. Physically bridges TLR4 and TICAM1 and functionally transmits LPS-TRL4 signal to TICAM1; signaling is proposed to occur in early endosomes after endocytosis of TLR4.
Immunogen: Synthetic peptide taken within amino acid region 140-170 on human TIRAP3b long form protein.
Expression: Expressed in spleen, prostate, testis, uterus, small intestine, colon, peripheral blood leukocytes, heart, placenta, lung, liver, skeletal muscle, and pancreas Isoform 2 is ubiquitously expressed (at lower levels than isoform 1). Molecular Function: Phospholipid binding, signal transducer activity
Structure: Homodimer. Interacts with TLR4, TICAM1, IRF3 and IRF7 in response to LPS. Interacts with IL1R1, IL1RAP, IRAK2, IRAK3 and TRAF6. Interacts with protein kinase-inactive mutants of IRAK1 and IRAK4. Isoform 1 interacts with isoform 2; the interaction occurs i
Subcellular Location: Isoform 1: Cytoplasm, Golgi apparatus, Cell membrane, Endoplasmic Reticulum, Early endosome membrane, Late endosome membrane. Isoform 2: Endoplasmic Reticulum, Early endosome membrane, Late endosome membrane. In general, we may offer more than one antibody to a given target to enable options for the researcher. Available antibodies recognizing TICAM2 are readily searchable from our website. Different antibodies against the same target such as TICAM2 may be optimized or tested for different applications and species. This enables researchers to select the option that may be best for their model system, to screen more than antibody to determine which one may be best for their model system, as well as to use more than one antibody to follow up on and validate their results. The following patways have been known to be associated with this gene.