anti-TIRAP antibody product blog
Tags: Antibody; Polyclonal Antibody; TIRAP; anti-TIRAP antibody;
The TIRAP tirap (Catalog #MBS151462) is an Antibody produced from Rabbit and is intended for research purposes only. The product is available for immediate purchase. The TIRAP Antibody reacts with Human and may cross-react with other species as described in the data sheet. MyBioSource\'s TIRAP can be used in a range of immunoassay formats including, but not limited to, ELISA (EIA), Western Blot (WB), Immunohistochemistry (IHC), Immunofluorescence (IF).TIRAP antibody can be used for detection of TIRAP by Western blot at 4 mug/mL. Antibody can also be used for immunohistochemistry starting at 20 mug/mL. For immunofluorescence start at 2 mug/mL. Researchers should empirically determine the suitability of the TIRAP tirap for an application not listed in the data sheet. Researchers commonly develop new applications and it is an integral, important part of the investigative research process.
The TIRAP tirap product has the following accession number(s) (GI #15705407) (NCBI Accession #AAL05627) (Uniprot Accession #P58753). Researchers may be interested in using Bioinformatics databases such as those available at The National Center for Biotechnology Information (NCBI) website for more information about accession numbers and the proteins they represent. Even researchers unfamiliar with bioinformatics databases will find the NCBI databases to be quite user friendly and useful.
To buy or view more detailed product information and pricing, please click on the technical datasheet page below:
Please refer to the product datasheet for known applications of a given antibody. We\'ve tested the TIRAP Antibody with the following immunoassay(s):
Western Blot (WB) (Western blot analysis of TIRAP in MCF-7 cell lysate with TIRAP antibody at 4 μg/mL.)
Immunohistochemistry (IHC) (Immunohistochemistry of TIRAP in human heart tissue with TIRAP antibody at 20 μg/mL.)
Immunofluorescence (IF) (Immunofluorescence of TIRAP in Human Heart cells with TIRAP antibody at 20 μg/mL.)
TIRAP Antibody: Toll-like receptors (TLRs) are signaling molecules that recognize different microbial products during infection and serve as an important link between the innate and adaptive immune responses. These proteins act through adaptor molecules such as TIRAP and MyD88 to activate various kinases and transcription factors. In TIRAP-deficient mice, TLR signaling in response to TLR2 ligands (using either TLR1 and TLR6 as co-receptors) is totally abolished, suggesting that MyD88 and TIRAP work together and are both required for TLR2 signaling. Furthermore, these mice are also resistant to the toxic effects of LPS and show defects in NF-κB and MAP kinase activation, suggesting that TIRAP is also involed in TLR4 signaling.
Conjugate: Unconjugated
Immunogen: TIRAP antibody was raised against a peptide corresponding to amino acids near the middle of human TIRAP.
Buffer: TIRAP Antibody is supplied in PBS containing 0.02% sodium azide. In general, we may offer more than one antibody to a given target to enable options for the researcher. Available antibodies recognizing TIRAP are readily searchable from our website. Different antibodies against the same target such as TIRAP may be optimized or tested for different applications and species. This enables researchers to select the option that may be best for their model system, to screen more than antibody to determine which one may be best for their model system, as well as to use more than one antibody to follow up on and validate their results.