anti-TDP1 antibody product blog
Tags: Antibody; Monoclonal Antibody; Tyrosyl-DNA phosphodiesterase 1; anti-TDP1 antibody; TDP1;
The TDP1 tdp1 (Catalog #MBS140331) is an Antibody produced from Mouse and is intended for research purposes only. The product is available for immediate purchase. MyBioSource\'s Tyrosyl-DNA phosphodiesterase 1 can be used in a range of immunoassay formats including, but not limited to, ELISA (EIA), Western Blot (WB).TDP1 antibody has been tested by ELISA and Western blot analysis to assure specificity and reactivity. Since application varies, however, each investigation should be titrated by the reagent to obtain optimal results. Recommended dilution range for Western blot analysis is 1:1000 ~ 2000. Recommended starting dilution is 1:1000. Researchers should empirically determine the suitability of the TDP1 tdp1 for an application not listed in the data sheet. Researchers commonly develop new applications and it is an integral, important part of the investigative research process.
The TDP1 tdp1 product has the following accession number(s) (GI #57242805) (NCBI Accession #NP_001008744.1). Researchers may be interested in using Bioinformatics databases such as those available at The National Center for Biotechnology Information (NCBI) website for more information about accession numbers and the proteins they represent. Even researchers unfamiliar with bioinformatics databases will find the NCBI databases to be quite user friendly and useful.
To buy or view more detailed product information and pricing, please click on the technical datasheet page below:
Introduction: TDP1 belongs to the phospholipase D family and contains two PLD phosphodiesterase domains. TDP1 is involved in repairing stalled topoisomerase I-DNA complexes by catalyzing the hydrolysis of the phosphodiester bond between the tyrosine residue of topoisomerase I and the 3-prime phosphate of DNA. TDP1 may also remove glycolate from single-stranded DNA containing 3-prime phosphoglycolate, suggesting a role in repair of free-radical mediated DNA double-strand breaks. Mutations in the TDP1 gene are linked to the disease spinocerebellar ataxia with axonal neuropathy (SCAN1).
Immunogen: Anti-human TDP1 mAb, is derived from hybridization of mouse F0 myeloma cells with spleen cells from BALB/c mice immunized with recombinant human TDP1 amino acids 1-298 purified from E Coli. In general, we may offer more than one antibody to a given target to enable options for the researcher. Available antibodies recognizing TDP1 are readily searchable from our website. Different antibodies against the same target such as TDP1 may be optimized or tested for different applications and species. This enables researchers to select the option that may be best for their model system, to screen more than antibody to determine which one may be best for their model system, as well as to use more than one antibody to follow up on and validate their results. TDP1 also interacts with the following gene(s): APTX, ATM, LIG3, PNKP, TOP1, XRCC1. Anemia, Cardiovascular Diseases, Cognition Disorders, Disease Models, Animal, Inflammation, Lung Neoplasms, Necrosis, Neoplasms, Experimental, Neutropenia, Spinocerebellar ataxia, autosomal recessive, with axonal neuropathy are some of the diseases may be linked to Mouse Anti Human Tyrosyl-DNA phosphodiesterase 1. Blood, Bone, Bone Marrow, Brain, Eye, Lung, Muscle, Skin, Spleen, Vascular tissues are correlated with this protein. The following patways have been known to be associated with this gene.