anti-TANK antibody product blog
Tags: Antibody; Polyclonal Antibody; TANK; anti-TANK antibody;
The TANK tank (Catalog #MBS151370) is an Antibody produced from Rabbit and is intended for research purposes only. The product is available for immediate purchase. The TANK Antibody reacts with Human, Mouse, Rat and may cross-react with other species as described in the data sheet. MyBioSource\'s TANK can be used in a range of immunoassay formats including, but not limited to, ELISA (EIA), Western Blot (WB), Immunohistochemistry (IHC), Immunofluorescence (IF).TANK antibody can be used for the detection of TANK by Western blot at 0.5 - 2 mug/mL. Antibody can also be used for immunohistochemistry starting at 10 mug/mL. For immunofluorescence start at 20 mug/mL. Researchers should empirically determine the suitability of the TANK tank for an application not listed in the data sheet. Researchers commonly develop new applications and it is an integral, important part of the investigative research process.
The TANK tank product has the following accession number(s) (GI #19743569) (NCBI Accession #NP_004171) (Uniprot Accession #Q92844). Researchers may be interested in using Bioinformatics databases such as those available at The National Center for Biotechnology Information (NCBI) website for more information about accession numbers and the proteins they represent. Even researchers unfamiliar with bioinformatics databases will find the NCBI databases to be quite user friendly and useful.
To buy or view more detailed product information and pricing, please click on the technical datasheet page below:
Please refer to the product datasheet for known applications of a given antibody. We\'ve tested the TANK Antibody with the following immunoassay(s):
Western Blot (WB) (Western blot analysis of TANK in human kidney tissue lysate with TANK antibody at (A) 1 and (B) 2 μg/mL.)
Immunohistochemistry (IHC) (Immunohistochemistry of TANK in rat spleen tissue with TANK antibody at 10 μg/mL.)
Immunofluorescence (IF) (Immunofluorescence of TANK in Rat Spleen cells with TANK antibody at 20 μg/mL.)
TANK Antibody: TANK was initially identified as a novel TRAF-interacting protein that regulated TRAF-mediated signal transduction. Specifically, ligand binding by surface receptors in the tumor necrosis factor (TNF) receptor and Toll/interleukin-1 (IL-1) receptor families lead to the formation of a TRAF/TANK complex that mediates the activation of the transcription factor NF-κB. This activation of NF-κB occurs through an association with the kinases IKKε and TBK1. More recently, it was shown that these proteins can then form a complex with NEMO, a protein that regulates the activity of the IκB complex. This suggests that in addition to the possibility that TBK1 and IKKε activate the IKKs, the association with the IKK complex may help these kinases modulate other functions, such as the transactivation potential of NF-κB proteins. At least two isoforms of TANK are known to exist.
Conjugate: Unconjugated
Immunogen: TANK antibody was raised against a 14 amino acid synthetic peptide from near the carboxy terminus of human TANK.
Buffer: TANK Antibody is supplied in PBS containing 0.02% sodium azide. In general, we may offer more than one antibody to a given target to enable options for the researcher. Available antibodies recognizing TANK are readily searchable from our website. Different antibodies against the same target such as TANK may be optimized or tested for different applications and species. This enables researchers to select the option that may be best for their model system, to screen more than antibody to determine which one may be best for their model system, as well as to use more than one antibody to follow up on and validate their results.