anti-SYN1 antibody product blog
Tags: Antibody; Polyclonal Antibody; anti-Syn1 antibody; Syn1; Synapsin I (Ser603);
The SYN1 syn1 (Catalog #MBS502119) is an Antibody produced from Rabbit and is intended for research purposes only. The product is available for immediate purchase. The Anti-Phospho-Ser603 Synapsin I reacts with Rat and may cross-react with other species as described in the data sheet. MyBioSource\'s Synapsin I (Ser603) can be used in a range of immunoassay formats including, but not limited to, Western Blot (WB).Quality Control: Western blots performed on each lot.
WB: 1:1000. Researchers should empirically determine the suitability of the SYN1 syn1 for an application not listed in the data sheet. Researchers commonly develop new applications and it is an integral, important part of the investigative research process.
The SYN1 syn1 product has the following accession number(s) (GI #27806393) (NCBI Accession #NP_776616.1) (Uniprot Accession #P17599). Researchers may be interested in using Bioinformatics databases such as those available at The National Center for Biotechnology Information (NCBI) website for more information about accession numbers and the proteins they represent. Even researchers unfamiliar with bioinformatics databases will find the NCBI databases to be quite user friendly and useful.
To buy or view more detailed product information and pricing, please click on the technical datasheet page below:
Please refer to the product datasheet for known applications of a given antibody. We\'ve tested the Anti-Phospho-Ser603 Synapsin I with the following immunoassay(s):
Testing Data
Affinity purified rabbit polyclonal antibody
Synapsin I plays a key role in synaptic plasticity in brain (Feng et al., 2002; Nayak et al., 1996). This effect is due in large part to the ability of the synapsins to regulate the availability of synaptic vesicles for release. The role of synapsin in synaptic plasticity and in synaptogensis is regulated by phosphorylation (Jovanovic et al., 2001; Kao et al., 2002). Serine 603 is the site on synapsin I that is phosphorylated by calcium calmodulin kinase II and by p21-activated kinases (Sakurada et al., 2002; Czernik et al., 1987). Phosphorylation of this site is thought to regulate synaptic vesicle function (Nayak et al., 1996; Bahler and Greengard, 1987; McGuinness et al., 1989).
Antigen: Phosphopeptide corresponding to amino acid residues surrounding the phospho-Ser603 of synapsin I.
Immunogen Information: Synthetic phospho-peptide corresponding to amino acid residues surrounding Ser603 conjugated to KLH
Immunogen Species: Rat. Reactivity Assumed Based on 100% Sequence Homology: Human, Xenopus, bovine, mouse, zebra fish
Species Reactivity Note: The antibody has been directly tested for reactivity in Western blots with rat tissue. It is anticipated that the antibody will react with bovine, human, mouse, Xenopus and zebra fish tissue based on the fact that these species have 100% homology with the amino acid sequence used as antigen. In general, we may offer more than one antibody to a given target to enable options for the researcher. Available antibodies recognizing SYN1 are readily searchable from our website. Different antibodies against the same target such as SYN1 may be optimized or tested for different applications and species. This enables researchers to select the option that may be best for their model system, to screen more than antibody to determine which one may be best for their model system, as well as to use more than one antibody to follow up on and validate their results.