|The SIRT6 sirt6 (Catalog #MBS621822) is an Antibody produced from Rabbit and is intended for research purposes only. The product is available for immediate purchase. The SIRT6, CT (Sirtuin 6, Sirtuin-6, Mono-ADP-ribosyltransferase Sirtuin-6, SIR2-like Protein 6, SIR2L6) reacts with Human and may cross-react with other species as described in the data sheet. MyBioSource\'s SIRT6 can be used in a range of immunoassay formats including, but not limited to, Western Blot (WB), Immunoprecipitation (IP), Immunofluorescence (IF).
Suitable for use in Immunofluorescence, Western Blot and Immunoprecipitation.
Dilution: Immunofluorescence: (IC) 1:100
Western Blot: 1:1000
Immunoprecipitation: 1:50. Researchers should empirically determine the suitability of the SIRT6 sirt6 for an application not listed in the data sheet. Researchers commonly develop new applications and it is an integral, important part of the investigative research process.
The SIRT6 sirt6 product has the following accession number(s) (GI #48146517) (Uniprot Accession #Q8N6T7). Researchers may be interested in using Bioinformatics databases such as those available at The National Center for Biotechnology Information (NCBI) website for more information about accession numbers and the proteins they represent. Even researchers unfamiliar with bioinformatics databases will find the NCBI databases to be quite user friendly and useful.
To buy or view more detailed product information and pricing, please click on the technical datasheet page below:
The Silent Information Regulator (SIR2) family of genes is a highly conserved group of genes that encode nicotinamide adenine dinucleotide (NAD)-dependent protein deacetylases, also known as Class III histone deacetylases. The first discovered and best characterized of these genes is Saccharomyces cerevisiae Sir2, which is involved in silencing of mating type loci, telomere maintenance, DNA damage response and cell aging. SirT6, a mammalian homolog of Sir2, is a nuclear, chromatin-associated protein that promotes the normal maintenance of genome integrity mediated by the base excision repair (BER) pathway. The BER pathway repairs single-stranded DNA lesions that arise spontaneously from endogenous alkylation, oxidation and deamination events. SirT6 deficient mice show increased sensitivity to DNA-damaging agents, including the alkylating agents MMS and H2O2. In addition, these mice show genome instability with increased frequency of fragmented chromosomes, detached centromeres and gaps. SirT6 may regulate the BER pathway by deacetylating DNA Pol-beta or other core components of the pathway.
Immunogen: Synthetic peptide (KLH-coupled) corresponding to the carboxy terminus of the human SirT6 protein. In general, we may offer more than one antibody to a given target to enable options for the researcher. Available antibodies recognizing SIRT6 are readily searchable from our website. Different antibodies against the same target such as SIRT6 may be optimized or tested for different applications and species. This enables researchers to select the option that may be best for their model system, to screen more than antibody to determine which one may be best for their model system, as well as to use more than one antibody to follow up on and validate their results. SIRT6 also interacts with the following gene(s): FLNA. Blood, Brain, Embryonic Tissue, Heart, Liver, Lung, Muscle, Prostate, Spleen, Stomach tissues are correlated with this protein.