anti-SIRPA antibody product blog
Tags: Antibody; Polyclonal Antibody; anti-SIRPA antibody; SIRPA; SIRP alpha (CT);
The SIRPA sirpa (Catalog #MBS194138) is an Antibody produced from Rabbit and is intended for research purposes only. The product is available for immediate purchase. MyBioSource\'s SIRP alpha (CT) can be used in a range of immunoassay formats including, but not limited to, Immunoblot.Immunoblotting : use a1:1,000-1:2,000 dilution.
Positive control: Whole cell lysate from THP-1 cells. Researchers should empirically determine the suitability of the SIRPA sirpa for an application not listed in the data sheet. Researchers commonly develop new applications and it is an integral, important part of the investigative research process.
The SIRPA sirpa product has the following accession number(s) (GI #18426911) (NCBI Accession #NP_542970.1) (Uniprot Accession #P78324). Researchers may be interested in using Bioinformatics databases such as those available at The National Center for Biotechnology Information (NCBI) website for more information about accession numbers and the proteins they represent. Even researchers unfamiliar with bioinformatics databases will find the NCBI databases to be quite user friendly and useful.
To buy or view more detailed product information and pricing, please click on the technical datasheet page below:
Protein tyrosine phosphatases (PTPases), such as SHP-1 and SHP-2, are critical regulators in the intracellular signaling pathways that result in cell responses such as mitosis, differentiation, migration, survival, transformation or death. SHP-2 is a signal transducer for several receptor tyrosine kinases and cytokine receptors. A novel SHP-2 associated glycoprotein was recently cloned from human, rat, mouse, and cattle by several laboratories and was designated SIRP alpha, SHPS-1, and MyD-1. SIRP alpha/SHPS-1 is a new gene family containing at least fifteen members. SIRP alpha/SHPS-1 is a substrate of many activated tyrosine kinases such as insulin receptor, EGFR, PDGFR, and src, and is a specific docking protein for SHP-2. SIRP alpha/SHPS-1 has regulatory effects on cellular responses induced by serum, growth factors, insulin, oncogenes, and cell adhesion and plays a general role in different physiological and pathological processes.
Antigen: Peptide corresponding to the Cterminus of human SIRP alpha. Stabilizer: None
Preservatives: 0.02% sodium azide
Dilutions Instructions: Dilute in PBS or medium which is identical to that used in the assay system. In general, we may offer more than one antibody to a given target to enable options for the researcher. Available antibodies recognizing SIRPA are readily searchable from our website. Different antibodies against the same target such as SIRPA may be optimized or tested for different applications and species. This enables researchers to select the option that may be best for their model system, to screen more than antibody to determine which one may be best for their model system, as well as to use more than one antibody to follow up on and validate their results. The following patways have been known to be associated with this gene. Anemia, Breast Neoplasms, Carcinoma, Congenital Abnormalities, Hypertension, Inflammation, Leukemia, Multiple Organ Failure, Necrosis, Prostatic Neoplasms are some of the diseases may be linked to Anti-SIRP alpha (CT) Antibody. SIRPA also interacts with the following gene(s): CD47, PTPN11, PTPN6. Brain, Embryonic Tissue, Eye, Heart, Kidney, Lung tissues are correlated with this protein.