anti-Serpinf2 antibody product blog
Tags: Antibody; Polyclonal Antibody; anti-SERPINF2 antibody; SERPINF2; Alpha2-antiplasmin;
The Serpinf2 serpinf2 (Catalog #MBS512008) is an Antibody produced from Goat and is intended for research purposes only. The product is available for immediate purchase.Suitable as a source of peroxidase-labeled antibodies to alpha2AP. Researchers should empirically determine the suitability of the Serpinf2 serpinf2 for an application not listed in the data sheet. Researchers commonly develop new applications and it is an integral, important part of the investigative research process.
The Serpinf2 serpinf2 product has the following accession number(s) (GI #6679383) (NCBI Accession #NP_032904.1) (Uniprot Accession #Q5ND36). Researchers may be interested in using Bioinformatics databases such as those available at The National Center for Biotechnology Information (NCBI) website for more information about accession numbers and the proteins they represent. Even researchers unfamiliar with bioinformatics databases will find the NCBI databases to be quite user friendly and useful.
To buy or view more detailed product information and pricing, please click on the technical datasheet page below:
alpha2Antiplasmin (alpha2AP), also known as alpha2Plasmin Inhibitor (alpha2PI), is a member of the SERPIN family of proteinase inhibitors and the primary inhibitor of the enzyme plasmin in blood. It is produced in the liver and circulates in plasma at ~70 ug/ml (~1 uM). alpha2AP is a single chain molecule with a mass of 67 kDa as determined by SDS-PAGE. The primary target enzyme for alpha2AP is plasmin, but alpha2AP also acts as secondary or "backup" inhibitor of activated F.XI, activated Protein C and trypsin. Inhibition of these enzymes by alpha2AP occurs by proteolytic cleavage after Arg364 with subsequent rapid formation of a stable, inactive 1:1 enzyme-alpha2AP complex. alpha2AP also acts to regulate fibrinolysis by binding to the lysine binding sites on plasminogen thus competitively inhibiting plasminogen binding to fibrin. About 30% of alpha2AP present in plasma is partially degraded and lacks a peptide in the carboxyl region that contains the plasminogen-binding site. This form of alpha2AP (~65 kDa) has a reduced rate of plasmin inhibition and has been referred to as the "slow form" of alpha2AP. During fibrin formation, a portion of circulating alpha2AP is cross-linked to the alpha-chain of fibrin by activated factor XIII, and this linking of plasmin inhibitor to the plasmin substrate provides an additional measure of protection to the fibrin clot from proteolysis by plasmin1-4.
Immunogen: Human alpha2antiplasmin purified from plasma. Buffer: A buffered stabilizer solution containing 50% (v/v) glycerol. In general, we may offer more than one antibody to a given target to enable options for the researcher. Available antibodies recognizing Serpinf2 are readily searchable from our website. Different antibodies against the same target such as Serpinf2 may be optimized or tested for different applications and species. This enables researchers to select the option that may be best for their model system, to screen more than antibody to determine which one may be best for their model system, as well as to use more than one antibody to follow up on and validate their results.