anti-SERPINA1 antibody product blog
Tags: Antibody; Polyclonal Antibody; SERPINA1; anti-SERPINA1 antibody; ALPHA 1 ANTITRYPSIN;
The SERPINA1 serpina1 (Catalog #MBS534535) is an Antibody produced from Rabbit and is intended for research purposes only. The product is available for immediate purchase. The alpha 1 Antitrypsin antibody reacts with Human and may cross-react with other species as described in the data sheet. MyBioSource\'s alpha 1 Antitrypsin can be used in a range of immunoassay formats including, but not limited to, Immunohistochemistry (IHC) Formalin/Paraffin.IHC-F: 1:100-1:200
IHC-P: 1:100-1:200. Researchers should empirically determine the suitability of the SERPINA1 serpina1 for an application not listed in the data sheet. Researchers commonly develop new applications and it is an integral, important part of the investigative research process.
The SERPINA1 serpina1 product has the following accession number(s) (GI #177831) (NCBI Accession #AAB59495.1) (Uniprot Accession #P01009). Researchers may be interested in using Bioinformatics databases such as those available at The National Center for Biotechnology Information (NCBI) website for more information about accession numbers and the proteins they represent. Even researchers unfamiliar with bioinformatics databases will find the NCBI databases to be quite user friendly and useful.
To buy or view more detailed product information and pricing, please click on the technical datasheet page below:
Please refer to the product datasheet for known applications of a given antibody. We\'ve tested the alpha 1 Antitrypsin antibody with the following immunoassay(s):
Immunohistochemistry (IHC) (Formalin-fixed, paraffin-embedded human tonsil stained with a-1-Antitrypsin (AAT) antibody using peroxidase-conjugate and AEC chromogen. Note cytoplasmic staining of endothelial cells.)
Rabbit polyclonal alpha 1 Antitrypsin antibody.
Biological Significance: Alpha-1-antitrypsin (alpha-1-AT) exists in a number of genetic variants. MM variant is the most common. Alpha-1-AT is synthesized in the liver and it acts as an inhibitor of proteases such as trypsin, elastase, chymotrypsin, collagenase, leucocytic proteases, plasmin, and thrombin, which may be released during inflammatory reactions in the lung. In the absence of alpha-1-AT, these enzymes are not inhibited and they may digest pulmonary parenchyma. Alpha-1-AT deficiency is associated with chronic obstructive lung disease (emphysema) and less frequently with hepatic cirrhosis in infants and respiratory distress of the newborn. Increase in alpha-1-AT occurs as an acute phase response to tissue necrosis and inflammation. Serum level of alpha-1-AT is elevated in rheumatoid arthritis, bacterial infections, vasculitis, and carcinomatosis. Cross-Reactivity: Baboon, horse, mink, monkey
Biohazard Information: This product contains sodium azide as preservative. Although the amount of sodium azide is very small appropriate care must be taken when handling.
Immunogen: Alpha 1 antitrypsin antibody was raised in rabbit using purified human serum Alpha-1-AT as the immunogen. In general, we may offer more than one antibody to a given target to enable options for the researcher. Available antibodies recognizing SERPINA1 are readily searchable from our website. Different antibodies against the same target such as SERPINA1 may be optimized or tested for different applications and species. This enables researchers to select the option that may be best for their model system, to screen more than antibody to determine which one may be best for their model system, as well as to use more than one antibody to follow up on and validate their results.