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anti-SERPINA1 antibody product blog

Posted on 2014-07-10 20:37:06 by mybiosource_staff
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Tags: Antibody; Polyclonal Antibody; SERPINA1; anti-SERPINA1 antibody; A-1-Antitrypsin;
The SERPINA1 serpina1 (Catalog #MBS373004) is an Antibody produced from Rabbit and is intended for research purposes only. The product is available for immediate purchase. The A-1-Antitrypsin reacts with Human and may cross-react with other species as described in the data sheet.

The SERPINA1 serpina1 product has the following accession number(s) (GI #1703025) (NCBI Accession #P01009.3) (Uniprot Accession #P01009). Researchers may be interested in using Bioinformatics databases such as those available at The National Center for Biotechnology Information (NCBI) website for more information about accession numbers and the proteins they represent. Even researchers unfamiliar with bioinformatics databases will find the NCBI databases to be quite user friendly and useful.

To buy or view more detailed product information and pricing, please click on the technical datasheet page below:

Please refer to the product datasheet for known applications of a given antibody. We\'ve tested the A-1-Antitrypsin with the following immunoassay(s):
Dilution Information
Dilution Information SERPINA1.

Immunohistochemistry (IHC)
Immunohistochemistry (IHC) SERPINA1.

Alpha-1-Antitrypsin (A1AT) is a glycoprotein generally known as serum trypsin inhibitor. Alpha-1-Antitrypsin is also referred to as alpha-1 proteinase inhibitor (A1PI) because it is a serine protease inhibitor (serpin), inhibiting a wide variety of proteases. It protects tissues from enzymes of infl ammatory cells, especially elastase, and has a reference range in blood of 1.5 – 3.5 gram/liter (in the U.S. the reference range is generally expressed as mg/dL or micromoles), but the concentration can rise many fold upon acute infl ammation. In its absence, elastase is free to break down elastin, which contributes to the elasticity of the lungs, resulting in respiratory complications such as emphysema, or COPD (Chronic Obstructive Pulmonary Disease) in adults and cirrhosis in adults or children. Alpha-1-Antitrypsin is considered to be very useful in the study of inherited AAT defi ciency, benign and Malignant Hepatic Tumors and Yolk-Sac Carcinomas. Positive staining for A-1-Antitrypsin may also be used in detection of benign and malignant lesions of a histiocytic nature. Sensitivity and specifi city of the results have made this antibody an useful tool in the screening of patients with Cryptogenic Cirrhosis or other forms of liver disease with portal fi brosis of unknown etiology.

Control: Tonsil, Lymph Node
Localization: Cytoplasmic. Reactivity Note: Paraffin, Frozen
Note: Concentrated Alpha-1-Antitrypsin antibody should be diluted to its working dilution in ImmunoDNA Background Blocker. In general, we may offer more than one antibody to a given target to enable options for the researcher. Available antibodies recognizing SERPINA1 are readily searchable from our website. Different antibodies against the same target such as SERPINA1 may be optimized or tested for different applications and species. This enables researchers to select the option that may be best for their model system, to screen more than antibody to determine which one may be best for their model system, as well as to use more than one antibody to follow up on and validate their results. SERPINA1 also interacts with the following gene(s): CTSG, PRTN3. Carcinoma, Carcinoma, Hepatocellular, Inflammation, Liver Cirrhosis, Liver Diseases, Lung Diseases, Neoplasms, Pulmonary Disease, Chronic Obstructive, Pulmonary Emphysema, alpha 1-Antitrypsin Deficiency are some of the diseases may be linked to A-1-Antitrypsin.
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