|The PSPH psph (Catalog #MBS140295) is an Antibody produced from Mouse and is intended for research purposes only. The product is available for immediate purchase. MyBioSource\'s Phosphoserine Phosphatase can be used in a range of immunoassay formats including, but not limited to, ELISA (EIA), Western Blot (WB).
PSPH antibody has been tested by ELISA and Western blot analysis to assure specificity and reactivity. Since application varies, however, each investigation should be titrated by the reagent to obtain optimal results. Recommended dilution range for Western blot analysis is 1:1,000 ~ 2,000. Recommended starting dilution is 1:1,000. Researchers should empirically determine the suitability of the PSPH psph for an application not listed in the data sheet. Researchers commonly develop new applications and it is an integral, important part of the investigative research process.
The PSPH psph product has the following accession number(s) (GI #46249388) (NCBI Accession #NP_004568.2). Researchers may be interested in using Bioinformatics databases such as those available at The National Center for Biotechnology Information (NCBI) website for more information about accession numbers and the proteins they represent. Even researchers unfamiliar with bioinformatics databases will find the NCBI databases to be quite user friendly and useful.
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Introduction: Human Phosphoserine phosphatase (hPSP) is an important enzyme in the phosphorylated pathway of serine biosynthesis, which contributes a major portion of the endogenous L-serine. Similar to known L-3-phosphoserine phosphatases, it catalyzed the Mg2+-dependent hydrolysis of L-phosphoserine and an exchange reaction between L-serine and L-phosphoserine. Recently, its complex structures reveal that the open-closed environmental change of the active site, generated -helical bundle domain, is important to substrate by local rearrangement of the recognition and hydrolysis.
Immunogen: Anti-human PSPH mAb, is derived from hybridization of mouse SP2/0 myeloma cells with spleen cells from BALB/c mice immunized with recombinant human PSPH amino acids 1-225 purified from E Coli. In general, we may offer more than one antibody to a given target to enable options for the researcher. Available antibodies recognizing PSPH are readily searchable from our website. Different antibodies against the same target such as PSPH may be optimized or tested for different applications and species. This enables researchers to select the option that may be best for their model system, to screen more than antibody to determine which one may be best for their model system, as well as to use more than one antibody to follow up on and validate their results. The following patways have been known to be associated with this gene. PSPH also interacts with the following gene(s): CBS, PSAT1, SHMT1, SHMT2. Breast Neoplasms, Cardiovascular Diseases, Fatty Liver, Fetal Growth Retardation, Heart Diseases, Hyperplasia, Hypertension, Inflammation, Lung Neoplasms, Neural Tube Defects are some of the diseases may be linked to Mouse Anti Human Phosphoserine Phosphatase. Blood, Bone, Brain, Eye, Liver, Lung, Lymph Node, Mouth, Skin, Vascular tissues are correlated with this protein.