|The PSMB8 psmb8 (Catalog #MBS633440) is an Antibody produced from Mouse and is intended for research purposes only. The product is available for immediate purchase. The PSMB8 (Proteasome Subunit beta Type-8, Proteasome Subunit beta-5i, Proteasome Component C13, Macropain Subunit C13, Multicatalytic Endopeptidase Complex Subunit C13, Low Molecular Mass Protein 7m Really Interesting New Gene 10 Protein, LMP7, PSMB5i, RING1 reacts with Human and may cross-react with other species as described in the data sheet. MyBioSource\'s PSMB8 can be used in a range of immunoassay formats including, but not limited to, ELISA (EL/EIA), Western Blot (WB), Immunohistochemistry (IHC), Immunofluorescence (IF).
Suitable for use in ELISA, Immunofluorescence, Immunohistochemistry and Western Blot.
Dilution: Immunohistochemistry (FFPE): 1.5ug/ml
Western Blot: 1:500-1:1,000. Researchers should empirically determine the suitability of the PSMB8 psmb8 for an application not listed in the data sheet. Researchers commonly develop new applications and it is an integral, important part of the investigative research process.
The PSMB8 psmb8 product has the following accession number(s) (GI #49456283) (Uniprot Accession #Q6FHU0). Researchers may be interested in using Bioinformatics databases such as those available at The National Center for Biotechnology Information (NCBI) website for more information about accession numbers and the proteins they represent. Even researchers unfamiliar with bioinformatics databases will find the NCBI databases to be quite user friendly and useful.
To buy or view more detailed product information and pricing, please click on the technical datasheet page below:
The proteasome is a multicatalytic proteinase complex with a highly ordered ring-shaped 20S core structure. The core structure is composed of 4 rings of 28 non-identical subunits; 2 rings are composed of 7 alpha subunits and 2 rings are composed of 7 beta subunits. Proteasomes are distributed throughout eukaryotic cells at a high concentration and cleave peptides in an ATP/ubiquitin-dependent process in a non-lysosomal pathway. An essential function of a modified proteasome, the immunoproteasome, is the processing of class I MHC peptides. This gene encodes a member of the proteasome B-type family, also known as the T1B family, that is a 20S core beta subunit. This gene is located in the class II region of the MHC (major histocompatibility complex). Expression of this gene is induced by gamma interferon and this gene product replaces catalytic subunit 3 (proteasome beta 5 subunit) in the immunoproteasome. Proteolytic processing is required to generate a mature subunit. Two alternative transcripts encoding two isoforms have been identified; both isoforms are processed to yield the same mature subunit.
Immunogen: Partial recombinant protein corresponding to a region near aa173-273 of human PSMB8 with a GST tag. In general, we may offer more than one antibody to a given target to enable options for the researcher. Available antibodies recognizing PSMB8 are readily searchable from our website. Different antibodies against the same target such as PSMB8 may be optimized or tested for different applications and species. This enables researchers to select the option that may be best for their model system, to screen more than antibody to determine which one may be best for their model system, as well as to use more than one antibody to follow up on and validate their results.