anti-PROS1 antibody product blog
Tags: Antibody; Polyclonal Antibody; PROTEIN S; anti-PROS1 antibody; PROS1;
The PROS1 pros1 (Catalog #MBS512137) is an Antibody produced from Sheep and is intended for research purposes only. The product is available for immediate purchase.Suitable as a source of peroxidase labelled antibodies to PS. Researchers should empirically determine the suitability of the PROS1 pros1 for an application not listed in the data sheet. Researchers commonly develop new applications and it is an integral, important part of the investigative research process.
The PROS1 pros1 product has the following accession number(s) (GI #27531066) (NCBI Accession #BAC54142.1) (Uniprot Accession #Q8IXC8). Researchers may be interested in using Bioinformatics databases such as those available at The National Center for Biotechnology Information (NCBI) website for more information about accession numbers and the proteins they represent. Even researchers unfamiliar with bioinformatics databases will find the NCBI databases to be quite user friendly and useful.
To buy or view more detailed product information and pricing, please click on the technical datasheet page below:
Protein S (PS) is a vitamin K dependent glycoprotein produced in the liver, endothelium and megakaryocytes. The concentration of PS in plasma is ~25 7g/ml (~325 nM) where it acts as a cofactor in the anticoagulant activity of activated Protein C. A deficiency of Protein S (quantitative or qualitative) is a risk factor for vascular thrombosis. Protein S is expressed as a single chain molecule with a molecular weight of 77 kDa. The structure of PS is similar to many other vitamin K dependent coagulation proteins, consisting of an N terminal calcium binding domain of 10 γ carboxyglutamic acid (gla) residues, followed by a thrombin sensitive loop region and 4 EGF like domains. The C terminal domain does not contain the usual catalytic triad of a proenzyme, but seems instead to be involved in the binding of PS to C4b binding protein (C4bp). Protein S binds to activated Protein C (APC) in the presence of calcium and negatively charged phospholipid surface to allow APC to proteolytically inactivate coagulation cofactors Va and VIIIa. Enzymatic regulation of PS cofactor activity is through cleavage of PS in the thrombin sensitive loop region by thrombin or other enzymes, resulting in the loss of calcium binding properties and APC cofactor activity. Another regulatory mechanism is to reduce the availability of PS by the binding of PS to C4bp. In plasma, approximately 60% of Protein S circulates in non covalent complex with C4bp, making it unavailable for APC cofactor activity. The binding of PS to C4bp may be important in localizing C4bp to damaged cell membranes where it may control activation of complement by the classical pathway.
Description: Vial containing 0.1ml of whole IgG conjugated to horseradish peroxidase (HRP) through carbohydrate groups. Total protein is 0.2mg
Immunogen: Human protein S purified form plasma
Buffer: A buffered stabilizer solution containing 50% (v/v) glycerol
Rz Ratio (Reinheitszahl A403/A280): 0.45 as determined spectrophotometrically
. In general, we may offer more than one antibody to a given target to enable options for the researcher. Available antibodies recognizing PROS1 are readily searchable from our website. Different antibodies against the same target such as PROS1 may be optimized or tested for different applications and species. This enables researchers to select the option that may be best for their model system, to screen more than antibody to determine which one may be best for their model system, as well as to use more than one antibody to follow up on and validate their results.