anti-PIWIL2 antibody product blog
Tags: Antibody; Polyclonal Antibody; PIWI-L2; anti-PIWIL2 antibody; PIWIL2;
The PIWIL2 piwil2 (Catalog #MBS150480) is an Antibody produced from Rabbit and is intended for research purposes only. The product is available for immediate purchase. The PIWI-L2 Antibody reacts with Human and may cross-react with other species as described in the data sheet. MyBioSource\'s PIWI-L2 can be used in a range of immunoassay formats including, but not limited to, ELISA (EIA), Immunohistochemistry (IHC).PIWI-L2 antibody can be used for detection of PIWI-L2 by immunohistochemistry at 5 mug/mL. Researchers should empirically determine the suitability of the PIWIL2 piwil2 for an application not listed in the data sheet. Researchers commonly develop new applications and it is an integral, important part of the investigative research process.
The PIWIL2 piwil2 product has the following accession number(s) (GI #24431985) (NCBI Accession #NP_00129193) (Uniprot Accession #Q8TC59). Researchers may be interested in using Bioinformatics databases such as those available at The National Center for Biotechnology Information (NCBI) website for more information about accession numbers and the proteins they represent. Even researchers unfamiliar with bioinformatics databases will find the NCBI databases to be quite user friendly and useful.
To buy or view more detailed product information and pricing, please click on the technical datasheet page below:
Please refer to the product datasheet for known applications of a given antibody. We\'ve tested the PIWI-L2 Antibody with the following immunoassay(s):
Immunohistochemistry (IHC) (Immunohistochemistry of PIWI-L2 in human brain tissue with PIWI-L2 antibody at 5 μg/mL.)
PIWI-L2 Antibody: PIWI-L2 is a member of the PIWI subfamily of Argonaute proteins, evolutionarily conserved proteins containing both PAZ and Piwi motifs that are crucial for the biogenesis and function of small non-coding RNAs and play important roles in stem cell self-renewal, RNA silencing, and translational regulation in diverse organisms. PIWI-L2 has been implicated in multiple roles including stem cell self-renewal and is highly expressed in many breast cancers. In these tumors, PIWI-L2 silences the expression of STAT3, a regulator of Bcl-XL and cyclin D1, allowing the proliferation and survival of breast cancer stem cells. Recent studies have shown that overexpression of PIWI-like proteins are potential biomarkers for colon and other cancers.
Conjugate: Unconjugated
Immunogen: PIWI-L2 antibody was raised against a 14 amino acid synthetic peptide near the center of human PIWI-L2.
Buffer: PIWI-L2 Antibody is supplied in PBS containing 0.02% sodium azide. In general, we may offer more than one antibody to a given target to enable options for the researcher. Available antibodies recognizing PIWIL2 are readily searchable from our website. Different antibodies against the same target such as PIWIL2 may be optimized or tested for different applications and species. This enables researchers to select the option that may be best for their model system, to screen more than antibody to determine which one may be best for their model system, as well as to use more than one antibody to follow up on and validate their results. The following patways have been known to be associated with this gene. Breast Neoplasms, Disease Models, Animal, Kidney Diseases, Liver Diseases, Liver Neoplasms are some of the diseases may be linked to PIWI-L2 Antibody.