anti-PHOX2B antibody product blog
Tags: Antibody; Polyclonal Antibody; PHOX2B; anti-PHOX2B antibody;
The PHOX2B phox2b (Catalog #MBS150210) is an Antibody produced from Rabbit and is intended for research purposes only. The product is available for immediate purchase. The PHOX2B Antibody reacts with Human, Mouse, Rat and may cross-react with other species as described in the data sheet. MyBioSource\'s PHOX2B can be used in a range of immunoassay formats including, but not limited to, ELISA (EIA), Western Blot (WB).PHOX2B antibody can be used for detection of PHOX2B by Western blot at 1 - 2 mug/mL. Researchers should empirically determine the suitability of the PHOX2B phox2b for an application not listed in the data sheet. Researchers commonly develop new applications and it is an integral, important part of the investigative research process.
The PHOX2B phox2b product has the following accession number(s) (GI #12707580) (NCBI Accession #NP_003915) (Uniprot Accession #Q99453). Researchers may be interested in using Bioinformatics databases such as those available at The National Center for Biotechnology Information (NCBI) website for more information about accession numbers and the proteins they represent. Even researchers unfamiliar with bioinformatics databases will find the NCBI databases to be quite user friendly and useful.
To buy or view more detailed product information and pricing, please click on the technical datasheet page below:
Please refer to the product datasheet for known applications of a given antibody. We\'ve tested the PHOX2B Antibody with the following immunoassay(s):
Western Blot (WB) (Western blot analysis of PHOX2B in 293 cell lysate with PHOX2B antibody at (A) 1 and (B) 2 μg/mL.)
PHOX2B Antibody: PHOX2A and PHOX2B (Paired mesoderm homeobox protein) are closely related, paired-homeodomain transcription factors that function as determinants of the noradrenergic phenotype during embryogenesis. PHOX2 proteins are crucial for the regulation of endogenous hydroxylases in neural crest cells and promote sympathetic neuron generation. Human PHOX2B contains one DNA binding homeobox domain and is required for the differentiation of all central and nonperipheral noradrenergic centers in the brain. In contrast, PHOX2A controls only the differentiation of the main noradrenergic center of the brain. Regulation of PHOX2 may have therapeutic utility in aging or disorders involving degeneration of noradrenergic neurons.
Conjugate: Unconjugated
Immunogen: PHOX2B antibody was raised against a 15 amino acid synthetic peptide near the center of human PHOX2B.
Buffer: PHOX2B Antibody is supplied in PBS containing 0.02% sodium azide. In general, we may offer more than one antibody to a given target to enable options for the researcher. Available antibodies recognizing PHOX2B are readily searchable from our website. Different antibodies against the same target such as PHOX2B may be optimized or tested for different applications and species. This enables researchers to select the option that may be best for their model system, to screen more than antibody to determine which one may be best for their model system, as well as to use more than one antibody to follow up on and validate their results. Central Nervous System Diseases, Chromosome Aberrations, Congenital Abnormalities, Congenital central hypoventilation syndrome, Crohn Disease, Embryo Loss, Hirschsprung Disease, Neurobehavioral Manifestations, Neuroblastoma, Weight Gain are some of the diseases may be linked to PHOX2B Antibody.