|The BIRC5 birc5 (Catalog #MBS540108) is an Antibody produced from Rabbit and is intended for research purposes only. The product is available for immediate purchase. The Phospho Survivin Antibody Affinity Purified reacts with Human, Mouse, Rat and may cross-react with other species as described in the data sheet. MyBioSource\'s Phospho-Survivin can be used in a range of immunoassay formats including, but not limited to, ELISA (EIA), Western Blot (WB).
Dot Blot: 1:10,000
Western Blot: 1:500. Researchers should empirically determine the suitability of the BIRC5 birc5 for an application not listed in the data sheet. Researchers commonly develop new applications and it is an integral, important part of the investigative research process.
The BIRC5 birc5 product has the following accession number(s) (GI #59859880) (NCBI Accession #NP_001012270.1) (Uniprot Accession #O15392). Researchers may be interested in using Bioinformatics databases such as those available at The National Center for Biotechnology Information (NCBI) website for more information about accession numbers and the proteins they represent. Even researchers unfamiliar with bioinformatics databases will find the NCBI databases to be quite user friendly and useful.
To buy or view more detailed product information and pricing, please click on the technical datasheet page below:
Please refer to the product datasheet for known applications of a given antibody. We\'ve tested the Phospho Survivin Antibody Affinity Purified with the following immunoassay(s):
Western Blot (WB)
Affinity Purified Phosphorylated Baculoviral IAP repeat-containing protein 5 isoform 2 Antibody
Multitasking protein that has dual roles in promoting cell proliferation and preventing apoptosis. Component of a chromosome passage protein complex (CPC) which is essential for chromosome alignment and segregation during mitosis and cytokinesis. Acts as an important regulator of the localization of this complex; directs CPC movement to different locations from the inner centromere during prometaphase to midbody during cytokinesis and participates in the organization of the center spindle by associating with polymerized microtubules. The complex with RAN plays a role in mitotic spindle formation by serving as a physical scaffold to help deliver the RAN effector molecule TPX2 to microtubules. May counteract a default induction of apoptosis in G2/M phase. The acetylated form represses STAT3 transactivation of target gene promoters. May play a role in neoplasia. Inhibitor of CASP3 and CASP7. Isoform 2 and isoform 3 do not appear to play vital roles in mitosis. Isoform 3 shows a marked reduction in its anti-apoptotic effects when compared with the displayed wild-type isoform.
Immunogen: Phosphorylated synthetic peptide corresponding to unique amino acid sequences on human Survivin protein.
Expression: Expressed only in fetal kidney and liver, and to lesser extent, lung and brain. Abundantly expressed in adenocarcinoma (lung, pancreas, colon, breast, and prostate) and in high-grade lymphomas. Also expressed in various renal cell carcinoma cell lines. Modification: Phosphorylated
Molecular Function: Protease inhibitor, Repressor, Thiol protease inhibitor
Structure: Monomer or Homodimer.
Subcellular Location: Cytoplasm, Nucleus, Chromsome, Centromere, Cytoskeleton, Spindle, Kinetochore, Midbody. In general, we may offer more than one antibody to a given target to enable options for the researcher. Available antibodies recognizing BIRC5 are readily searchable from our website. Different antibodies against the same target such as BIRC5 may be optimized or tested for different applications and species. This enables researchers to select the option that may be best for their model system, to screen more than antibody to determine which one may be best for their model system, as well as to use more than one antibody to follow up on and validate their results.