anti-PGR antibody product blog
Tags: Antibody; Progesterone Receptor; PGR; Polyclonal Antibody; anti-PGR antibody;
The PGR pgr (Catalog #MBS625349) is an Antibody produced from Rabbit and is intended for research purposes only. The product is available for immediate purchase. The Progesterone Receptor, phosphorylated (Ser190) (Nuclear Receptor Subfamily 3 Group C Member 3, PR, NR3C3, PGR) reacts with Human and may cross-react with other species as described in the data sheet. MyBioSource\'s Progesterone Receptor can be used in a range of immunoassay formats including, but not limited to, Western Blot (WB), Immunohistochemistry (IHC), Immunofluorescence (IF).Suitable for use in Immunofluorescence, Western Blot, and Immunohistochemistry.
Dilution: Immunofluorescence: 1:100-1:200
Western Blot: 1:500-1:1,000
Immunohistochemistry: 1:50-1:100. Researchers should empirically determine the suitability of the PGR pgr for an application not listed in the data sheet. Researchers commonly develop new applications and it is an integral, important part of the investigative research process.
The PGR pgr product has the following accession number(s) (GI #189935) (Uniprot Accession #P06401). Researchers may be interested in using Bioinformatics databases such as those available at The National Center for Biotechnology Information (NCBI) website for more information about accession numbers and the proteins they represent. Even researchers unfamiliar with bioinformatics databases will find the NCBI databases to be quite user friendly and useful.
To buy or view more detailed product information and pricing, please click on the technical datasheet page below:
Progesterone plays a central role in the reproductive events associated with the establishment and maintenance of pregnancy. Progesterone receptor, a member of the steroid receptor superfamily, mediates the physiologic effects of progesterone. The PGR gene uses separate promoters and translational start sites to produce 2 isoforms, PRA and PRB, which are identical except for an additional 165 amino acids present only in the N terminus of PRB. Although PRA and PRB share several structural domains, they are distinct transcription factors that mediate their own response genes and physiologic effects with little overlap.[supplied by OMIM].
Immunogen: Synthetic phosphopeptide corresponding to human Progesterone Receptor around the phosphorylation site of serine 190 (G-L-SP-P-A). In general, we may offer more than one antibody to a given target to enable options for the researcher. Available antibodies recognizing PGR are readily searchable from our website. Different antibodies against the same target such as PGR may be optimized or tested for different applications and species. This enables researchers to select the option that may be best for their model system, to screen more than antibody to determine which one may be best for their model system, as well as to use more than one antibody to follow up on and validate their results. Brain, Cervix, Lung, Mammary Gland, Muscle, Ovary, Prostate, Stomach, Uterus, Vascular tissues are correlated with this protein. The following patways have been known to be associated with this gene. PGR also interacts with the following gene(s): ESR1, KLF9, NCOA1, NCOA3, RELA, SP1, SRC. Adenocarcinoma, Breast Neoplasms, Carcinoma, Female Urogenital Diseases, Genital Neoplasms, Female, Neoplasm Recurrence, Local, Neoplasms, Neoplasms, Experimental, Neoplasms, Hormone-Dependent, Uterine Neoplasms are some of the diseases may be linked to Progesterone Receptor, phosphorylated (Ser190) (Nuclear Receptor Subfamily 3 Group C Member 3, PR, NR3C3, PGR).