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anti-PF4V1 antibody product blog

Posted on 2015-03-13 14:32:46 by mybiosource_staff
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Tags: Antibody; Platelet Factor 4; PF4V1; Monoclonal Antibody; anti-PF4V1 antibody;
The PF4V1 pf4v1 (Catalog #MBS520516) is an Antibody produced from Mouse and is intended for research purposes only. The product is available for immediate purchase. The Anti-Human Platelet Factor 4 (requires heparin for binding), Biotin (Clone: KKO) (Mouse IgG2b) reacts with Human and may cross-react with other species as described in the data sheet. MyBioSource\'s Platelet Factor 4 can be used in a range of immunoassay formats including, but not limited to, ELISA (EIA), Western Blot (WB).
This antibody is suitable for use in ELISA and Western Blot. Researchers should empirically determine the suitability of the PF4V1 pf4v1 for an application not listed in the data sheet. Researchers commonly develop new applications and it is an integral, important part of the investigative research process.

The PF4V1 pf4v1 product has the following accession number(s) (GI #292390) (NCBI Accession #AAA60067.1) (Uniprot Accession #P10720). Researchers may be interested in using Bioinformatics databases such as those available at The National Center for Biotechnology Information (NCBI) website for more information about accession numbers and the proteins they represent. Even researchers unfamiliar with bioinformatics databases will find the NCBI databases to be quite user friendly and useful.

To buy or view more detailed product information and pricing, please click on the technical datasheet page below:

Platelet factor IV is a 70 aa protein released from the alpha granules of activated platelets. PF4 is synthesized by bone marrow megakaryocytes and stored in alpha granules as a non-covalent bound tetramer. Platelet factor IV binds with high affinity to heparin and plays a role in inflammation and wound repair. PF4 is a chemoattractant for neutrophils, monocytes and fibroblasts and has been reported to be an immunologic regulator that inhibits suppressor T-cell activity. Heparin-Induced Thrombocytopenia/Thrombosis (HIT/HITT) is a life-threatening complication that manifests itself in a small population of patients exposed to intravenous-heparin. It is characterized by the production of PF4/heparin auto-antibodies. These auto-antibodies bind the PF4/heparin complexes and subsequently bind the FcgammaIIa receptor on the platelets surface through their Fc region. This activates the platelets and can initiate clot formation. (clone KKO), unlike (clone RTO) which binds PF4 alone, is specific for PF4/heparin complexes and is seen to have similar binding properties as auto-antibodies found in HIT/HITT.

PF4V1 pf4v1

Immunogen: Human Factor IV purified from the supernatant of thrombin activated platelets. Presentation: Biotin conjugated IgG buffered in PBS, 0.02% NaN3 and EIA grade BSA as a stabilizing protein to bring total protein concentration to 4-5 mg/mL. In general, we may offer more than one antibody to a given target to enable options for the researcher. Available antibodies recognizing PF4V1 are readily searchable from our website. Different antibodies against the same target such as PF4V1 may be optimized or tested for different applications and species. This enables researchers to select the option that may be best for their model system, to screen more than antibody to determine which one may be best for their model system, as well as to use more than one antibody to follow up on and validate their results.
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