anti-PCSK9 antibody product blog
Tags: Antibody; PCSK9; anti-PCSK9 antibody;
The PCSK9 pcsk9 (Catalog #MBS462174) is an Antibody produced from Rabbit and is intended for research purposes only. The product is available for immediate purchase. The Rabbit anti PCSK9 antibody reacts with Human, Rat, Mouse, Gorilla and may cross-react with other species as described in the data sheet. MyBioSource\'s PCSK9 can be used in a range of immunoassay formats including, but not limited to, ELISA, Western Blot, Immunohistochemistry.Western Blot: 0.1-1 ug/ml
ELISA: 0.01-0.1 ug/ml
Immunoprecipitation: 2-5 ug/ml. Researchers should empirically determine the suitability of the PCSK9 pcsk9 for an application not listed in the data sheet. Researchers commonly develop new applications and it is an integral, important part of the investigative research process.
The PCSK9 pcsk9 product has the following accession number(s) (GI #31317307) (NCBI Accession #NP_777596.2) (Uniprot Accession #Q8NBP7). Researchers may be interested in using Bioinformatics databases such as those available at The National Center for Biotechnology Information (NCBI) website for more information about accession numbers and the proteins they represent. Even researchers unfamiliar with bioinformatics databases will find the NCBI databases to be quite user friendly and useful.
To buy or view more detailed product information and pricing, please click on the technical datasheet page below:
Please refer to the product datasheet for known applications of a given antibody. We\'ve tested the Rabbit anti PCSK9 antibody with the following immunoassay(s):
Western Blot (WB) ( Western Blot: The whole cell lysate derived from HT-29 (lane 1), Mouse Liver (lane 2), mouse lung (lane 3) were immunoblotted by Rabbit anti-PCSK9 (Cat#MBS462174))
Proprotein convertase subtilisin/kexin type 9 (PCSK9) is a member of the serine protease family with a critical role in cholesterol metabolism by controlling the levels of low density lipoprotein (LDL) particles that circulate in the bloodstream. Mutation in the PCSK9 gene is associated with autosomal dominant hypercholesterolemia which is characterized by an increase in LDL cholesterol levels. PCSK9 is expressed in various tissues such as liver, kidney, lung, spleen, etc. Human PCSK9 precursor is 692 aa protein with 74kDa molecular weight. Its mature form has molecular weight ranging of 62-66 kDa in the tissues.
Antigen Preparation: A synthetic peptide derived from 100aa-300aa of Human PCSK9 protein. This sequence is identical among human, rat, mouse, gorilla, etc. Positive Control: HT-29, or mouse liver. In general, we may offer more than one antibody to a given target to enable options for the researcher. Available antibodies recognizing PCSK9 are readily searchable from our website. Different antibodies against the same target such as PCSK9 may be optimized or tested for different applications and species. This enables researchers to select the option that may be best for their model system, to screen more than antibody to determine which one may be best for their model system, as well as to use more than one antibody to follow up on and validate their results. Bone, Brain, Embryonic Tissue, Intestine, Liver, Ovary, Pancreas, Skin, Stomach, Uterus tissues are correlated with this protein. PCSK9 also interacts with the following gene(s): LDLR. Arteriosclerosis, Coronary Artery Disease, Dyslipidemias, HYPERCHOLESTEROLEMIA, AUTOSOMAL DOMINANT, 3, Hypercholesterolemia, Hyperlipidemias, Liver Diseases, Myocardial Ischemia, Obesity, PROPROTEIN CONVERTASE, SUBTILISIN/KEXIN-TYPE, 9 are some of the diseases may be linked to Rabbit anti PCSK9 antibody.