anti-p53 antibody product blog
Tags: Antibody; anti-p53 antibody; p53; Monoclonal Antibody;
The p53 tp53 (Catalog #MBS140121) is an Antibody produced from Mouse and is intended for research purposes only. The product is available for immediate purchase. MyBioSource\'s p53 can be used in a range of immunoassay formats including, but not limited to, Western Blot (WB), Immunoprecipitation (IP).Western Blotting: 2ug/ml. Researchers should empirically determine the suitability of the p53 tp53 for an application not listed in the data sheet. Researchers commonly develop new applications and it is an integral, important part of the investigative research process.
The p53 tp53 product has the following accession number(s) (GI #120407068) (NCBI Accession #NP_000537.3). Researchers may be interested in using Bioinformatics databases such as those available at The National Center for Biotechnology Information (NCBI) website for more information about accession numbers and the proteins they represent. Even researchers unfamiliar with bioinformatics databases will find the NCBI databases to be quite user friendly and useful.
To buy or view more detailed product information and pricing, please click on the technical datasheet page below:
Description: Monoclonal antibodies are produced by immunizing mouse with full length His-tagged p53 protein.
Introduction: p53 is a tumor suppressor gene expressed in a wide variety of tissue types and is involved in regulating cell growth, replication, and apoptosis. It binds to mdm2, SV40 T antigen and human papilloma virus E6 protein p53 senses DNA damage and possibly facilitating repair. Mutation involving p53 is found in a wide variety of malignant tumors, including breast, ovarian, bladder, colon, lung, and melanoma.
In general, we may offer more than one antibody to a given target to enable options for the researcher. Available antibodies recognizing p53 are readily searchable from our website. Different antibodies against the same target such as p53 may be optimized or tested for different applications and species. This enables researchers to select the option that may be best for their model system, to screen more than antibody to determine which one may be best for their model system, as well as to use more than one antibody to follow up on and validate their results. Bladder, Blood, Bone, Brain, Liver, Lung, Lymph, Lymph Node, Prostate, Skin tissues are correlated with this protein. The following patways have been known to be associated with this gene. Breast Neoplasms, Carcinoma, Carcinoma, Small Cell, Carcinoma, Squamous Cell, Cell Transformation, Neoplastic, Colorectal Neoplasms, Glioma, Liver Neoplasms, Neoplasm Metastasis, Sarcoma are some of the diseases may be linked to Mouse Anti p53.