anti-ORAI1 antibody product blog
Tags: Antibody; Polyclonal Antibody; ORAI1; anti-ORAI1 antibody;
The ORAI1 orai1 (Catalog #MBS612091) is an Antibody produced from Rabbit and is intended for research purposes only. The product is available for immediate purchase. The ORAI1, CT (Transmembrane Protein 142A, TMEM142A, Calcium Release-Activated Calcium Channel Protein 1) reacts with Human, Mouse, Rat and may cross-react with other species as described in the data sheet. MyBioSource\'s ORAI1 can be used in a range of immunoassay formats including, but not limited to, Western Blot (WB).Suitable for use in Western Blot.
Dilution: Western Blot: 0.5-1ug/ml, detects a band of approximately 49kD in 49 cell lysates.
Optimal dilution to be determined by researcher. Researchers should empirically determine the suitability of the ORAI1 orai1 for an application not listed in the data sheet. Researchers commonly develop new applications and it is an integral, important part of the investigative research process.
The ORAI1 orai1 product has the following accession number(s) (GI #15426546) (Uniprot Accession #Q96D31). Researchers may be interested in using Bioinformatics databases such as those available at The National Center for Biotechnology Information (NCBI) website for more information about accession numbers and the proteins they represent. Even researchers unfamiliar with bioinformatics databases will find the NCBI databases to be quite user friendly and useful.
To buy or view more detailed product information and pricing, please click on the technical datasheet page below:
ORAI1, also known as Transmembrane protein 142A (TMEM142A), a 32.7 kD multi-pass membrane protein belonging to the ORAI family. Antigen stimulation of immune cells triggers Ca2+ entry through Ca2+ release-activated Ca2+ (CRAC) channels. CRAC channels are the main pathway for Ca2+ influx in T-cells and promote the immune response to pathogens by activating the transcription factor NFAT. ORAI1 is a four- transmembrane spanning protein that is an essential component of CRAC. ORAI1 functions as a highly selective Ca2+ plasma membrane channel that is gated through interactions with STIM1, the store-activated endoplasmic reticulum Ca2+ sensor. Defective ORAI1 in humans is the cause of one form of hereditary severe combined immune deficiency (SCID), which results in ablated T-cell Ca2+ entry.
Immunogen: A 16 amino acid peptide from near the carboxy terminus of human ORAI1. In general, we may offer more than one antibody to a given target to enable options for the researcher. Available antibodies recognizing ORAI1 are readily searchable from our website. Different antibodies against the same target such as ORAI1 may be optimized or tested for different applications and species. This enables researchers to select the option that may be best for their model system, to screen more than antibody to determine which one may be best for their model system, as well as to use more than one antibody to follow up on and validate their results. The following patways have been known to be associated with this gene. Blood, Bone, Brain, Embryonic Tissue, Eye, Heart, Intestine, Kidney, Lung, Salivary Gland tissues are correlated with this protein. ORAI1 also interacts with the following gene(s): TRPC3, TRPC6.