anti-NLRP3 antibody product blog
Tags: Antibody; Monoclonal Antibody; anti-NLRP3 antibody; NLRP3; NLRP3/NALP3;
The NLRP3 nlrp3 (Catalog #MBS644925) is an Antibody produced from Mouse and is intended for research purposes only. The product is available for immediate purchase. MyBioSource\'s NLRP3/NALP3 can be used in a range of immunoassay formats including, but not limited to, Western Blot (WB).Suitable for use in Western Blot
Wester Blot: 1ug/ml
Optimal dilutions to be determined by researcher. Researchers should empirically determine the suitability of the NLRP3 nlrp3 for an application not listed in the data sheet. Researchers commonly develop new applications and it is an integral, important part of the investigative research process.
The NLRP3 nlrp3 product has the following accession number(s) (GI #341865590) (NCBI Accession #NP_001230062.1) (Uniprot Accession #Q96P20). Researchers may be interested in using Bioinformatics databases such as those available at The National Center for Biotechnology Information (NCBI) website for more information about accession numbers and the proteins they represent. Even researchers unfamiliar with bioinformatics databases will find the NCBI databases to be quite user friendly and useful.
To buy or view more detailed product information and pricing, please click on the technical datasheet page below:
Please refer to the product datasheet for known applications of a given antibody. We\'ve tested the NLRP3/NALP3 (NACHT-, LRR- and PYD-containing Protein 3, NLRP3, Cryopyrin, Cold Autoinflammatory Syndrome 1 Protein) with the following immunoassay(s):
Western Blot (WB) (WB: NLRP3 is detected in mouse macrophages using MBS644925. Cell extracts from mouse macrophages, WT (lane 1) or NLRP3 KO (lane 2), were separated by SDS-PAGE under reducing conditions, transferred to nitrocellulose and incubated with MBS644925 (1ug/ml). Proteins were visualized by a chemiluminescence detection system.)
The inflammasome is a multiprotein complex that mediates the activation of caspase-1, which promotes, amongst others, the secretion of the proinflammatory cytokines interleukin (IL)-1beta and IL-18. Members of the Nod-like receptor family, including NLRP3 / NALP3, are critical components of the inflammasome that link danger-signals to caspase-1 activation. Defects in NLRP3 are the cause of familial cold autoinflammatory syndrome type 1 (FCAS1), Muckly-Wells sydrome (MWS) and of chronic infantile neurologic cutaneous and articular syndrome (CINCA).
Immunogen: Recombinant mouse NLRP3/NALP3 (pyrin domain/aa 1-93). In general, we may offer more than one antibody to a given target to enable options for the researcher. Available antibodies recognizing NLRP3 are readily searchable from our website. Different antibodies against the same target such as NLRP3 may be optimized or tested for different applications and species. This enables researchers to select the option that may be best for their model system, to screen more than antibody to determine which one may be best for their model system, as well as to use more than one antibody to follow up on and validate their results. Blood, Bone Marrow, Brain, Connective Tissue, Intestine, Lung, Pancreas, Prostate, Thymus tissues are correlated with this protein. The following patways have been known to be associated with this gene. Cardiovascular Diseases, Cryopyrin-Associated Periodic Syndromes, Disease Models, Animal, FAMILIAL COLD AUTOINFLAMMATORY SYNDROME 1, Inflammation, Lung Diseases, MUCKLE-WELLS SYNDROME, Necrosis, Respiratory Tract Diseases, Vascular Diseases are some of the diseases may be linked to NLRP3/NALP3 (NACHT-, LRR- and PYD-containing Protein 3, NLRP3, Cryopyrin, Cold Autoinflammatory Syndrome 1 Protein).