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anti-MUC5AC antibody product blog

Posted on 2014-09-01 01:52:48 by mybiosource_staff
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Tags: Antibody; MUC5AC; Monoclonal Antibody; anti-MUC5AC antibody;
The MUC5AC n/a (Catalog #MBS370143) is an Antibody produced from Mouse and is intended for research purposes only. The product is available for immediate purchase. The MUC5AC reacts with Human and may cross-react with other species as described in the data sheet.

The MUC5AC n/a product has the following accession number(s) (GI #15026993). Researchers may be interested in using Bioinformatics databases such as those available at The National Center for Biotechnology Information (NCBI) website for more information about accession numbers and the proteins they represent. Even researchers unfamiliar with bioinformatics databases will find the NCBI databases to be quite user friendly and useful.

To buy or view more detailed product information and pricing, please click on the technical datasheet page below:

Please refer to the product datasheet for known applications of a given antibody. We\'ve tested the MUC5AC with the following immunoassay(s):
Dilution Information
Dilution Information MUC5AC.

Immunohistochemistry (IHC)
Immunohistochemistry (IHC) MUC5AC.

Mucin 5AC, also known as MUC5AC, is a human gene. The Mucin 5AC antigen is found in columnar mucous cells of surface gastric epithelium and in goblet cells of the fetal and precancerous colon but not in normal colon cells. Mucin genes are expressed in a regulated cell- and tissue-specific manner. MUC1 is detected in mucous cells of the surface epithelium and neck region of the gastric antrum, as well as in pyloric glands and oxynthic glands of the body region. MUC5AC is highly expressed in foveolar epithelium of both body and antrum, whereas MUC6 protein expression is limited to mucous neck cells of the body and pyloric glands of the antrum. The mucin expression pattern of Gastric Carcinoma is heterogeneous. It includes mucins normally expressed in gastric mucosa (MUC1, MUC5AC and MUC6) and de novo expression of the intestinal mucin MUC2. The heterogeneous pattern of mucin expression, including the expression of the intestinal mucin MUC2, may provide new insights into the differentiation pathways of Gastric Carcinoma. It has been shown that in Gastric Carcinomas evaluated for expression of several mucins (MUC1, MUC2, MUC5AC and MUC6), mucin expression is associated with tumor type (MUC5AC with Diffuse and Infiltrative Carcinomas and MUC2 with Mucinous Carcinomas) but not with the clinico-biological behavior of the tumors. Mucin expression is associated with tumor location (MUC5AC with Antrum Carcinomas and MUC2 with Cardia Carcinomas), indirectly reflecting differences in tumor differentiation according to tumor location.

Control: Stomach
Localization: Cytoplasmic. Reactivity Note: Paraffin, Frozen. In general, we may offer more than one antibody to a given target to enable options for the researcher. Available antibodies recognizing MUC5AC are readily searchable from our website. Different antibodies against the same target such as MUC5AC may be optimized or tested for different applications and species. This enables researchers to select the option that may be best for their model system, to screen more than antibody to determine which one may be best for their model system, as well as to use more than one antibody to follow up on and validate their results.
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